Study on the Risk of Metabolic Syndrome Based on UA/Cr Analysis

Abstract

To explore the epidemiological trend of the relationship between serum uric acid/creatinine ratio(UA/Cr) and metabolic syndrome (MS) in middle-aged and old people in Wuhan, Hubei Province. The study used the method of cluster sampling, In 2016, 6570 residents over 45 years old in Wuhan City, Hubei Province were investigated with standardized questionnaire, physical examination and biochemical examination. MS is defined according to the standard of the International Diabetes Union. According to the quartile grouping of UA/Cr, the regression analysis of risk metabolism indexes between UA / Cr and MS was carried out. Analyze the correlation between UA / Cr and MS to determine whether UA / Cr can be an independent risk factor of MS.6414 subjects were included in this study including 3313 MS patients (52.7%). Blood CR level is 77(70~87) mmol/L,Blood UA level is 314(267~372) mmol/L,UA/Cr level is 4.01(3.46~4.65). The study population was divided into four groups according to the UA / Cr quartile.Group 1 UA/Cr <1.0, Group 2 1.0≤UA/Cr<1.5,Group 3 1.5≤UA/Cr<2.0,Group 4 UA/Cr≥2.0. From the first group to the fourth group, with the increase of UA / Cr level, the body mass index (BMI), waist circumference, blood pressure, triacylglycerol, low-density lipoprotein cholesterol, total cholesterol, C-reactive protein and insulin resistance increased gradually (P < 0.01). The prevalence of MS and its components also increased significantly (P < 0.01).Conclusion:There was an independent positive correlation between UA / Cr and MS in the middle-aged and old people in the community, UA / Cr can be used as early biomarker of MS. It provides a new scientific basis for the early detection of MS, the intervention of high-risk population and the reversal of cardiovascular disease.