Intervention Effect of Compatibility of Salvianolic Acid A & B on PDGF-C/PDGFR-α Signaling Pathway in Renal Fibrosis
Keywords:
Salvianolic acid A, Salvianolic acid B, PDGF-C/PDGFR-α, Signaling pathway, Interstitial fibrosis
Abstract
Objective: To explore the effect of salvianolic acid A & B component molecules of drug compatibility on PDGF-c/PDGFR-α signaling pathway in renal fibrosis of rats. Methods: 40 male SPF SD rats were randomly divided into four groups: control group, salvianolic acid A group, salvianolic acid B group and salvianolic acid A + B group, with 10 rats in each group. Each group was treated for two weeks. After the intervention, samples were collected. And scores of HE and Masson was compared. The expression of PDGF-c/PDGFR-α in rental tissue in them was also tested and compared. Results: Compared with the control group, the score of HE and Masson in intervention groups was markedly decreased, and scores in salvianolic acid B group and salvianolic acid A + B group were reduced significantly (p < 0.05); Compared with the control group, the expression of PDGF-c/PDGFR-α in rental tissue in intervention groups was lower(p < 0.05), especially in salvianolic acid B group and salvianolic acid A + B group (p < 0.05).Conclusion: salvianolic acid A & B component molecules of drug compatibility could significantly improve the pathological changes in the kidney tissue of rats, suppress the expression of PDGF-c/PDGFR-α in renal tissue, and improve the renal function, renal tubular function and renal pathology.References
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2. Zhou J, Lu H, Lu M, et al. Protective effect of B on experimental renal interstitial fibrosis in rats and its mechanism. Chinese Herbal Medicine. 2010;33(11):1755‒1759.
3. Wang D, Li J, Cao Y, et al. Effect of on the differentiation of renal tubular epithelial cells in rats with renal fibrosis model. Journal of Shanghai University of Traditional Chinese Medicine. 2012;26(1):68‒72.
4. Weiwei W, Zhang J. Effects of salvianolic acid B on Aristolochic Acid induced HK-2 cell TGF beta 1 and p38MAPK expression. The Chinese and Western Medicine Combined With Nephropathy Magazine. 2010;11(4):57‒61.
5. He L, Huang D, et al. Salvianolic acid B to improve the mechanism of aristolochic acid nephropathy. Journal of Xi’an Jiaotong University (Medical Sciences). 2010;31(6):766‒769.
Published
2015-06-20
Issue
Section
Original Research Article
Copyright (c) 2015 Bin Yu
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