The predictive value of CysC combined with NGAL in critical newborns with acute kidney injury
Abstract
To investigate the predictive value of cystatin C (CysC) combined with neutrophil gelatinase-associated lipocalin (NGAL) in critically ill newborns with acute kidney injury (AKI).The data of 143 critically ill newborns admitted to the NICU from October 2022 to October 2024 were retrospectively analyzed. They were divided into non-AKI group (114 cases) and AKI group (29 cases) based on whether they had AKI. The clinical data of the two groups were compared. CysC and NGAL were detected at admission to the NICU and 24 hours after admission to the NICU. The levels of CysC and NGAL were compared between the non-AKI group and the AKI group, and an ROC curve was drawn to evaluate the predictive value of CysC and NGAL on AKI in critical newborns.The levels of CysC and NGAL in the AKI group were measured upon admission to the NICU and 24 hours post-admission. Both markers were significantly higher compared to the non-AKI group (P < 0.05). The ROC curve showed that CysC and NGAL have predictive value for identifying critically ill neonates in the NICU. Specifically, the AUC values for predicting AKI in infants were 0.895 for CysC and 0.835 for NGAL, with a combined prediction AUC of 0.948. Furthermore, when measured 24 hours after NICU admission, the AUC values for predicting critical neonatal AKI were 0.798 for CysC and 0.806 for NGAL, with a combined forecast AUC of 0.847.CysC and NGAL have the value of predicting AKI in critically ill newborns. Compared with testing after admission to the NICU, the combined testing of CysC and NGAL when first admitted to the NICU has a better predictive effect on AKI.
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