Clinical Study of Simple Plasma Exchange in the Treatment of Severe Autoimmune Hepatitis

  • Qiaoai Hong
  • Xiaoping Xu
  • Maojun Yao
  • Zhangshu Qu
DOI: https://doi.org/10.18686/aem.v4i2.57
Keywords: Plasma exchange, Autoimmune hepatitis, Clinical efficacy

Abstract

Objectives: Plasma Exchange (PE) in the treatment of severe autoimmune hepatitis and the clinical outcome of the clinical data were retrospectively analyzed. The clinical efficacy and safety of single plasma exchange (PE) in the treatment of autoimmune hepatitis were also evaluated. Method: The PE group of 22 patients was given conventional treatment of combined treatment of patients with simple PE while 21 cases of the control group were treated with comprehensive treatment. The efficacy of PE group and control group were compared within 2 weeks. Results: The clinical symptoms of 22 patients in PE group were significantly improved (p < 0.05); in total bilirubin (TBIL), (AST), (INR), (ALT) where the PE group (17/22) 77.27%, and control group (10/21) 47.62%. The difference was statistically significant (p < 0.05). Conclusion: Pure plasma exchange (PE) is an effective method for the treatment of severe autoimmune hepatitis (AIH).

References

1. Lapierre P, Beland K, Alvarez F. Pathogenesis of autoimmune hepatitis: from break of tolerance to immune-mediated hepatocy teapoptosis. Transl Res. 2007;149(3):107‒113.
2. Wang J, Chen M. Guangdong medical advances in diagnosis and treatment of autoimmune hepatitis. Research Progress in Immunology. 2008;29(7):1078‒1079.
3. Chen Q. The diagnosis and treatment of autoimmune hepatitis. Clinical Liver and Gallbladder Diseases Journal. 2007;23(6):457‒459.
4. Czaja AJ, Freese DK. Diagnosis and treatment of autoimmune hepatitis. Hepatology. 2002;36:479‒497.
5. Chen J, Sun L, Zhou Z, et al. Efficacy of artificial liver support system for treatment of chronic severe hepatitis B. Liver. 2010;15(2):118‒120.
6. Hou W, Tu W, Jin Q, et al. Clinical analysis of 30 cases of liver failure treated with. Chinese Modern Doctor. 2012;50(35):31‒33.
Published
2015-06-11
Issue
Vol 4 No 2 (2015)
Section
Original Research Article

Copyright (c) 2015 Qiaoai Hong, Xiaoping Xu, Maojun Yao, Zhangshu Qu

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Authors submitting to USP journals agree to publish their manuscript under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0) where authors agree to allow third parties to share their work (copy, distribute, transmit) and to adapt it, under the condition that the authors are given credit, and that in the event of reuse or distribution, the terms of this license are made clear

Authors retain copyright of their work, with first publication rights (online and print) granted to Universe Scientific Publishing or the owner of the journal in question.