Clinical Study of Azithromycin in Treatment of Respiratory Tract Infections in Children

  • Fei Qian
  • Ershang Yang
  • Haoyuan Zheng
Keywords: Azithromycin, Erythromycin, Children, Respiratory tract infection

Abstract

Objective: To observe the clinical efficacy and safety of azithromycin in the treatment of respiratory tract infections in children. Method: This study was select 110 cases of respiratory tract infection in our hospital from April 2013 to December 2014 as the research object. According to the random grouping method, the children were divided into two groups, 55 cases in the control group and 55 cases in the treatment group. On the basis of conventional treatment, the control group was treated with erythromycin 15 to 30 mg/kg per day for 1 week while for the treatment group was treated with Azithromycin 10 mg/kg per day by intravenous drip, and 8 mg/kg per day was administered orally for 4 days. To observe the clinical symptoms, signs, chest X-ray and adverse reactions of two groups before and after treatment. Results: The treatment group cure rate was significantly higher than that of the control group (p < 0.05), cough and fever disappearance time is shorter than that of the control group (p < 0.05), adverse reactions occurred rate of treatment group was lower than that of the control group (p < 0.05). Conclusion: The efficacy of azithromycin in the treatment of respiratory tract infections in children is reliable, less adverse reactions and it is worthy of promotion.

References

1. Qi Y. Azithromycin Sequential Therapy in the treatment of severe pneumonia mycoplasma pneumonia curative effect observation. Journal of Applied Clinical Pediatrics. 2003;18(10):847‒848.
2. Yin T, Jiang Y. Study on the treatment of mycoplasma pneumonia in children with azithromycin and erythromycin. Chinese Journal of antibiotics.2002;27(4):240‒241.
3. Li Z. Ceftriaxone with azithromycin in treatment of children with acute lower respiratory tract infection curative effect observation. The Hospital Infection Journal. 2013;11(10):2728‒2730.
4. Li XH. Azithromycin Sequential Therapy Combined with Tanreqing Injection in the treatment of children with acute lower respiratory tract infection in 60 cases clinical analysis . Contemporary Chinese Medicine. 2012;20(2):95‒97.
5. Luan JQ. Cephalosporins combined with azithromycin in the treatment of children with acute lower respiratory tract infection of efficacy and safety evaluation. Chinese Modern Drug Application. 2010;19(17):110‒111.
Published
2015-05-13
Section
Original Research Article