Severe Myelosuppression Induced by Piperacillin/Tazobactam: A Case Report

  • Aiyun Huang Chongqing University Cancer Hospital
  • Liya Tian Chongqing University Cancer Hospital
Keywords: Piperacillin/Tazobactam; Myelosuppression; Adverse Drug Reaction


This case report presents an elderly patient who developed severe bone marrow suppression following the administration of Piperacillin/Tazobactam. The patient exhibited a declining trend in platelet and white blood cell counts during Piperacillin/Tazobactam treatment. Subsequently, upon discontinuation of Piperacillin/Tazobactam, platelet and white blood cell counts gradually increased. Negative drug allergy test results and the absence of evidence for bone marrow suppression caused by platelet antibodies or other drugs led to the consideration of the possibility of immune-mediated bone marrow suppression induced by Piperacillin/Tazobactam. This report emphasizes the importance of close monitoring of hematological parameters to mitigate the risk of bone marrow suppression during the clinical use of Piperacillin/Tazobactam.


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Review Article