Mesenchymal stem cells secretions for treating neurological diseases and their mechanism of action
Abstract
Neurological diseases are a class of diseases that seriously affect human health, including stroke, Parkinson’s disease, Alzheimer’s disease and spinal cord injury. Traditional treatments have some limitations in the treatment of these diseases, such as drug side effects, surgical risks, etc. In recent years, secretions from mesenchymal stem cells (MSCs) have attracted much attention as a new method to treat neuro_x005flogical diseases. The secretions are composed of a variety of bioactive components, which can exert their therapeutic effects by regulating the inflammatory response, promoting the regeneration and repair of nerve cells, and resisting oxidative stress. This review aims to review the application of MSC secretions in the treatment of neurological diseases and explore the mechanism of action.
References
[1]Xue Xiaoyan, Guo Xiaohua, Li Min, et al. Progress in the pathogenesis of neurodegenerative diseases [J]. Chinese Journal of Gerontology, 2015,35 (11): 3149-3152.
[2] JARMALAVIČIŪTĖ A, PIVORIŪNAS A. Exosomes as a potential novel therapeutic tools against neurodegenerative diseases.
Pharmacol Res. 2016;113(Pt B):816-822.
[3] KESHTKAR S, AZARPIRA N, GHAHREMANI MH. Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine. Stem Cell Res Ther. 2018;9(1):63.
[4] Chen Chen, Huang Hui, Hu Wenjia, Li Xiangyong. Mesenchymal stem cell-derived exosomes for neurodegenerative diseases: problems in application and future prospects [J]. Tissue Engineering Research, China, 2019,23 (9): 1441-1447. DOI:10.3969/j.issn.2095-4344.1582
[5] Lo Furno D, Mannino G , Giuffrida R. Functional role of mesenchymal stem cells in the treatment of chronic neurodegenerative
diseases. J Cell Physiol. 2018;233(5): 3982-3999.
[6] GAO ZC, LIU X. The role and application of mesenchymal stem cells-derived exosomes in the treatment of nervous system diseases. Zhongguo Zuzhi Gongcheng Yanjiu. 2020;24(19):3048-3054. DOI:10.3969/j.issn.2095-4344.2040.
[7] SUGAYA K, VAIDYA M. Stem Cell Therapies for Neurodegenerative Diseases. Adv Exp Med Biol. 2018;1056: 61-84.
[8] VIZOSO FJ, EIRO N, CID S, et al. Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative
Medicine. Int J Mol Sci. 2017;18(9):E1852.
[9] DENG H, SUN C, SUN Y , et al. Lipid, Protein, and MicroRNA Composition Within Mesenchymal Stem Cell-Derived Exosomes.
Cell Reprogram. 2018;20(3):178-186
[10] ZHANG H, WANG Y , LV Q, et al. MicroRNA-21 Overexpression Promotes the Neuroprotective Efficacy of Mesenchymal Stem
Cells for Treatment of Intracerebral Hemorrhage. Front Neurol. 2018;9:931.
[11] Wei Yufan, Fan Feiyan, Li Shuangli, Zhang Yunke. The future of exosomes and mesenchymal stem cells-derived exosomes in the
diagnosis and treatment of Parkinson’s disease [J]. China Tissue Engineering Research, 2022,26 (25): 4076-4083.
[12] DING M, SHEN Y , WANG P , et al. Exosomes Isolated From Human Umbilical Cord Mesenchymal Stem Cells Alleviate
Neuroinflammation and Reduce Amyloid-Beta Deposition by Modulating Microglial Activation in Alzheimer’s Disease. Neurochem Res.
2018;43(11):2165-2177.
[13] LIEW LC, KATSUDA T , GAILHOUSTE L, et al. Mesenchymal stem cell-derived extracellular vesicles: a glimmer of hope in
treating Alzheimer’s disease. Int Immunol. 2017;29(1):11-19.
[14] Golden Saint Yu, Green lett. Progress of mesenchymal stem cell exosomes in the treatment of Alzheimer’s disease [J]. Chinese
Journal of Cell and Stem Cell: Electronic edition, 2019,9 (4): 247-250
[15] Wang Weili, Song vicissitudes of life. Progress in the pathogenesis of Alzheimer’s disease and clinical medication [J]. Drug Evaluation in China, 2019,36 (3): 204-209
[16] Feng Shiqing. Current status and outlook of basic research on spinal cord injury [J]. Chinese Journal of Experimental Surgery,
2021,38 (7): 1193-1198.
[17] LI D, ZHANG P , YAO X, et al. Exosomes Derived From miR-133b-Modified Mesenchymal Stem Cells Promote Recovery After
Spinal Cord Injury. Front Neurosci. 2018;12:845.
[18] Zhang Y , Chopp M, Liu XS, et al. Exosomes Derived from Mesenchymal Stromal Cells Promote Axonal Growth of Cortical
Neurons. Mol Neurobiol. 2017;54(4):2659-2673.
[19] Chang YH, Wu KC, Harn HJ, et al. Exosomes and Stem Cells in Degenerative Disease Diagnosis and Therapy. Cell Transplant.
2018;27(3):349-363.（
[20] Gao Zhen orange, Liu Xin. Role and application of mesenchymal stem cells in the repair of nervous system diseases [J]. China
Tissue Engineering Research, 2020,24 (19): 3048-3054. DOI:10.3969/j.issn.2095-4344.2040
[21] Ferguson SW, Wang J, Lee CJ, et al. The microRNA regulatory landscape of MSC-derived exosomes: a systems view. Sci Rep.
2018;8(1):1419.
[22] LAI RC, YEO RW, LIM SK. Mesenchymal stem cell exosomes. Semin Cell Dev Biol. 2015;40:82-88
[23] PHINNEY DG , PITTENGER MF . Concise Review: MSC-Derived Exosomes for Cell-Free Therapy. Stem Cells.
2017;35(4):851-858.
Authors submitting to USP journals agree to publish their manuscript under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0) where authors agree to allow third parties to share their work (copy, distribute, transmit) and to adapt it, under the condition that the authors are given credit, and that in the event of reuse or distribution, the terms of this license are made clear
Authors retain copyright of their work, with first publication rights (online and print) granted to Universe Scientific Publishing or the owner of the journal in question.
