Research Progress on the effect of High altitude and hypoxia on Mitochondrial function in Obesity
Abstract
Obesity is one of the diseases that threaten human health at present, and it can lead to the increasing prevalence of related complications, such as Insulin resistance, Non-alcoholic fatty liver diseases NAFLD and Type 2 diabetes mellitus and so on. In the whole world, the prevalence rate of obesity is on the rise. Insulin resistance is one of the most common complications of obesity. More and more studies have shown that there is a close relationship between mitochondrial dysfunction and insulin resistance. Skeletal muscle is an important target organ of insulin. Skeletal muscle mitochondrial dysfunction can lead to abnormal glucose and lipid metabolism and further affect the signal pathway of energy metabolism. The new epidemiological survey shows that the prevalence of obesity in high altitude areas is significantly lower than that in plain areas, and the prevalence of overweight and obesity is negatively correlated with altitude. This paper discusses the relationship between high altitude hypoxia and mitochondrial metabolism.
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