Research progress of embryonic stem cells in treatment of spinal cord injury
Abstract
Spinal Cord Injury (SCI) refers to the structural and functional injury of the spinal cord under external forces. The spinal cord is an important part of the human nervous system, responsible for transmitting information between the brain and the rest of the body. Spinal cord injury may lead to varying degrees of neurological dysfunction, including impaired sensory, motor, autonomic, and vesical and intestinal functions [1]. Traditional treatments for patients often fail to fully restore their function, so it is particularly important to find a new treatment [2]. As a kind of cell with the ability of self-replication and multidirectional differentiation, stem cells have been widely used in the treatment of spinal cord injury, showing great potential in the treatment of spinal cord injury and achieving certain clinical effects [3]. This article reviews the research progress of embryonic stem cells in spinal cord injury, aiming to explore the application status, mechanism and prospect of stem cells in the treatment of spinal cord injury, and provide scientific basis for clinical treatment.
References
[1] Zrzavy T, Schwaiger C, Wimmer I, et al. Acute and non-resolving inflammation associate with oxidative injury after human spinal
cord injury. Brain. 2021;144(1):144-161. doi:10.1093/brain/awaa360
[2] Ahuja CS, Nori S, Tetreault L, et al. Traumatic Spinal Cord Injury-Repair and Regeneration. Neurosurgery. 2017;80(3S):S9-S22.
doi:10.1093/neuros/nyw080
[3] Jin Yuanzhi, Rong Xin, Liu Hao. Research progress of stem cell transplantation in different stages of traumatic spinal cord injury
[J]. Chinese Journal of Prosthoplastic and Reconstructive Surgery, 2019,37(06):721-726. (in Chinese)Choong C, Rao MS. Human embryonic
stem cells. Neurosurg Clin N Am. 2007;18(1):1-vii. doi:10.1016/j.nec.2006.10.004
[4] Kim DH, Cho HJ, Park CY, Cho MS, Kim DW. Transplantation of PSA-NCAM-Positive Neural Precursors from Human Embryonic Stem Cells Promotes Functional Recovery in an Animal Model of Spinal Cord Injury [published correction appears in Tissue Eng Regen
Med. 2022 Oct 26;:]. Tissue Eng Regen Med. 2022;19(6):1349-1358. doi:10.1007/s13770-022-00483-z
[5] Jones I, Novikova LN, Wiberg M, Carlsson L, Novikov LN. Human Embryonic Stem Cell-derived Neural Crest Cells
Promote Sprouting and Motor Recovery Following Spinal Cord Injury in Adult Rats. Cell Transplant. 2021;30:963689720988245.
doi:10.1177/0963689720988245
[6] Wang Y, Pan J, Wang D, Liu J. The Use of Stem Cells in Neural Regeneration: A Review of Current Opinion. Curr Stem Cell Res
Ther. 2018;13(7):608-617. doi:10.2174/1574888X13666180720100738
[7] Luo H, Chen X, Zhuang P, Wu S, Wei J, Xu W. Cotransplantation with RADA16-PRG-Self-Assembled Nanopeptide Scaffolds,
Bone Mesenchymal Stem Cells and Brain-Derived Neurotrophic Factor-Adeno-Associated Virus Promote Functional Repair After Acute Spinal Cord Injury in Rats. J Biomed Nanotechnol. 2022;18(1):225-233. doi:10.1166/jbn.2022.3216
[8] Tang Y, Xu Z, Tang J, et al. Architecture-Engineered Electrospinning Cascade Regulates Spinal Microenvironment to Pro_x005fmote Nerve Regeneration [published correction appears in Adv Healthc Mater. 2023 Jul;12(18):e2301754]. Adv Healthc Mater.
2023;12(12):e2202658. doi:10.1002/adhm.202202658
[9] Lowry N, Goderie SK, Lederman P, et al. The effect of long-term release of Shh from implanted biodegradable microspheres on
recovery from spinal cord injury in mice. Biomaterials. 2012;33(10):2892-2901. doi:10.1016/j.biomaterials.2011.12.048
[10]Zeb H, Khan IN, Munir I, et al. Updates on Therapeutics in Clinical Trials for Spinal Cord Injuries: Key Translational Applications
of Human Embryonic Stem Cells-Derived Neural Progenitors. CNS Neurol Disord Drug Targets. 2016;15(10):1266-1278. doi:10.2174/1871
527315666161004145709
[11]Alessandrini M, Preynat-Seauve O, De Bruin K, Pepper MS. Stem cell therapy for neurological disorders. S Afr Med J.
2019;109(8b):70-77. Published 2019 Sep 10. doi:10.7196/SAMJ.2019.v109i8b.14009
[12]Gao L, Peng Y, Xu W, et al. Progress in Stem Cell Therapy for Spinal Cord Injury. Stem Cells Int. 2020;2020:2853650. Published
2020 Nov 5. doi:10.1155/2020/2853650
[13]Dalamagkas K, Tsintou M, Seifalian AM. Stem cells for spinal cord injuries bearing translational potential. Neural Regen Res.
2018 Jan;13(1):35-42. doi: 10.4103/1673-5374.224360. PMID: 29451202; PMCID: PMC5840986.
[14]Tsuji O, Miura K, Fujiyoshi K, Momoshima S, Nakamura M, Okano H. Cell therapy for spinal cord injury by neural stem/progenitor cells derived from iPS/ES cells. Neurotherapeutics. 2011 Oct;8(4):668-76. doi: 10.1007/s13311-011-0063-z. PMID: 21909829; PMCID:
PMC3250290.
[15]Heng BC, Liu H, Cao T. Utilising human embryonic stem cells as “catalysts” for biological repair and regeneration. Challenges
and some possible strategies. Clin Exp Med. 2005;5(1):37-39. doi:10.1007/s10238-005-0063-6
[16]Hashii N, Kawasaki N, Nakajima Y, et al. Study on the quality control of cell therapy products. Determination of N-glycolylneuraminic acid incorporated into human cells by nano-flow liquid chromatography/Fourier transformation ion cyclotron mass spectrometry. J
Chromatogr A. 2007;1160(1-2):263-269. doi:10.1016/j.chroma.2007.05.062
[17]Gazdic M, Volarevic V, Harrell CR, Fellabaum C, Jovicic N, Arsenijevic N, Stojkovic M. Stem Cells Therapy for Spinal Cord Injury. Int J Mol Sci. 2018 Mar 30;19(4):1039. doi: 10.3390/ijms19041039. PMID: 29601528; PMCID: PMC5979319.
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