Immunoinflammatory mechanism of severe pneumonia and the application of inflammatory markers in clinical practice
Abstract
Pneumonia is a common disease and one of the leading causes of morbidity and mortality worldwide. [1] Severe pneumonia is a unique clinical disease that is highly life-threatening, characterized by severe sepsis, septic shock, or respiratory failure. Usually, treatment is required in the intensive care unit (ICU). Approximately 10% of community-acquired pneumonia (CAP) patients require hospitalization, with a mortality rate of 21% -47%. Most patients with severe community-acquired pneumonia have complications, including chronic obstructive pulmonary disease, diabetes and coronary heart disease. Streptococcus pneumoniae, Staphylococcus aureus, Mycoplasma pneumoniae, aaLe_x005fgionella, Klebsiella pneumoniae, Haemophilus influenzae, novel coronavirus, respiratory virus and Pseudomonas aeruginosa are important pathogenic microorganisms for severe CAP. [2] Host autoimmune factors, patient clinical manifestations, and laboratory and imaging examination results at admission can help identify high-risk populations for this disease. Early identification and timely empirical application of antibiotics are particularly important for the prognosis of patients.
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