The Role of the Pro-Apoptotic Protein Bax in Colon Cancer

  • Jiazhe Feng University of Glasgow
Keywords: Bax;Apoptosis; Colon Cancer


Bax is a pro-apoptotic member of the Bcl-2 family that plays a crucial role in the regulation of apoptosis. Bax can be activated by various stimuli and translocate to the mitochondria, where it induces cytochrome c release and caspase activation. Bax expression or activity can be altered in colon cancer cells, resulting in resistance to apoptosis and tumor progression. This article summarized the molecular mech-anisms of Bax activation and function in apoptosis, the alterations of Bax expression or activity in colon cancer cells, and the potential thera-peutic implications of targeting Bax or its regulators in colon cancer.


[1] Li, P., Dong, R., Zhang, B., Zhang, T., Liu, Z., Ma, S., & Ma, L. (2021). Molecular mechanism and therapeutic targeting of necrosis, apoptosis, pyroptosis, and autophagy in cardiovascular disease. Chinese Medical Journal, 134(22), 2647-2655.

[2] Spitz, A. Z., & Gavathiotis, E. (2022). Physiologic and Pharmacologic Modulation of BAX. Trends in Pharmacological Sciences,

43(3), 206.

[3] Ichim, G., & Tait, S. W. (2016). A fate worse than death: Apoptosis as an oncogenic process. Nature Reviews Cancer, 16(8), 539-


[4] Liu, Z., Ding, Y., Ye, N., Wild, C., Chen, H., & Zhou, J. (2016). Direct Activation of Bax Protein for Cancer Therapy. Medicinal

Research Reviews, 36(2), 313.

[5] Walensky, L. D. (2019). Targeting BAX to drug death directly. Nature Chemical Biology, 15(7), 657-665.

Review Article