The Effect of Hypertriglyceridemia on the Development of Acute Pancreatitis and the Extent of Its Pathological Damage

  • Juan Qian
Keywords: Hypertriglyceridemia; Acute Pancreatitis; Pathological Damage; Lipid Metabolism


This paper investigates the effect of hypertriglyceridemia on the development of acute pancreatitis and the extent of its pathological damage. It was found that hypertriglyceridemia has a significant correlation with the development of acute pancreatitis, and it may trigger acute pancreatitis by increasing blood viscosity and affecting microcirculation, leading to a decrease in pancreatic blood flow, which puts the pancreatic cells in a state of ischaemia and hypoxia. At the same time, hypertriglyceridemia can also affect the lipid metabolism and immune function of the pancreas, aggravating the progression of the disease and pathological damage. The influence of hypertriglyceridemia on the course of acute pancreatitis and the degree of pathological damage was confirmed through the analysis of specific clinical cases. On this basis, the possible mechanisms of hypertriglyceridemia on the degree of pathological damage in acute pancreatitis were explored, and possible mechanisms were proposed to affect the blood supply to the pancreas, to disrupt the balance of lipid metabolism in the pancreas, to affect the function of the immune system, and to directly affect the accumulation of pancreatic fluids and digestion.


Wei YW.Research progress on pathogenesis and treatment of hypertriglyceridemic pancreatitis[J]. Progress of Modern General Surgery in China, 2020, 23(7): 4.

Wang YZ, Gu XJ, Wu J, et al. Analysis of risk factors for severe hypertriglyceridemic acute pancreatitis[J]. Chongqing Medicine,2023,52(1):6.

Qi YL. Clinical characteristics of acute pancreatitis associated with severe hypertriglyceridemia[J], 2020.

Wang Z, Liu X, He Q, et al. Progress of clinical research on hypertriglyceridemic acute pancreatitis[J]. Journal of Luzhou Medical College,2022(1):45.

Original Research Article