Identification of Potential Therapeutic Targets Inducible Co-Stimulator (ICOS) in Cancer Immunotherapy Using Bioinformatics Analysis

  • Qingjie Guo ZIBO Vocational Institute
DOI: https://doi.org/10.18686/aem.v12i2.389
Keywords: ICOS, Cancer, Lymphocytes, Immunotherapy, Prognosis

Abstract

Clinical trials testing Inducible Co-Stimulator (ICOS) agonists in cancers are under way. However, Co-expression and Interaction of ICOS at the Gene and Protein Levels, the correlations of ICOS to prognosis and tumor-infiltrating lymphocytes in different cancers remain unclear. ICOS expression was analyzed via the Oncomine database and Tumor Immune Estimation Resource (TIMER) site. Analysis of the expression difference of ICOS shows that the expression of ICOS is significantly increased in BRCA, ESCA, HNSC, KIRC, KIRP, LIHC, STAD and UCEC. We evaluated the influence of ICOS on clinical prognosis using Kaplan-Meier plotter and Gene Expression Profiling Interactive Analysis (GEPIA). This analysis confirmed that low ICOS expression was significantly correlated with poor overall survival (OS) and progression-free survival (PFS) in ovarian cancer. The correlations between ICOS and cancer immune infiltrates were investigated via TIMER. Metascape and Protein-protein interaction (PPI) analysis suggest that ICOS plays an important role in the process of immune activation. ICOS is a potential target for the development of antibody drugs.

References

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Published
2023-06-01
Issue
Vol 12, No 2 (2023)
Section
Original Research Article

Copyright (c) 2023 Qingjie Guo

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