Effect of Mechanical Ventilation Combined with Budesonide Suspension on Pulmonary Function Indices in the Treatment of Severe Asthma

  • Rong Fan Jingzhou First People's Hospital
  • Wei Xiao Jingzhou First People's Hospital
  • Weihua Hu Jingzhou First People's Hospital
  • Zhu Wu Jingzhou First People's Hospital
DOI: https://doi.org/10.18686/aem.v12i2.387
Keywords: Severe Asthma, Mechanical Ventilation, Budesonide, Lung Function, Adverse Effects

Abstract

Objective: To observe the effectiveness of different methods in the treatment of severe asthma. Methods: Ninety patients admitted from 2020.2 to 2022.8 were divided into groups A and B, 45 patients each, and all were given basic symptomatic treatment, group A was given nebulized inhalation of budesonide suspension, group B was mechanically ventilated on the basis of group A's protocol, and the treatment was compared between groups. Results: After 3 weeks of continuous treatment, the lung function (FEV1, PEF, FEV1/FVC) levels of patients in group B were higher than those in group A, and the difference reached a significant level (P < 0.05). The incidence of adverse reactions in groups A and B was 8.89% and 6.67% respectively, which was not statistically significant (P > 0.05). Conclusion: In patients with severe asthma, early mechanical ventilation with inhalation of budesonide suspension can improve lung function more rapidly and with higher safety, and is worth promoting.

References

[1] Ren W. Clinical observation of budesonide nebulized inhalation combined with methylprednisolone in the treatment of severe bronchial asthma [J]. China Pharmaceutical Guide, 2019, 17(01): 92-93.

[2] Lv P. Clinical effects of interferon combined with budesonide in the treatment of pediatric asthma [J]. Journal of Clinical Rational Drug Use,2022,15(29):129-132.

[3] Xie H, Wan QQ, Lin HY, Gan HL. Study on the efficacy of high-flow humidified oxygen therapy in the adjunctive treatment of severe asthma[J]. Heilongjiang Medicine, 2021, 34(05):1129-1131.
Published
2023-06-01
Issue
Vol 12, No 2 (2023)
Section
Original Research Article

Copyright (c) 2023 Rong Fan, Wei Xiao, Weihua Hu, Zhu Wu

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Authors submitting to USP journals agree to publish their manuscript under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0) where authors agree to allow third parties to share their work (copy, distribute, transmit) and to adapt it, under the condition that the authors are given credit, and that in the event of reuse or distribution, the terms of this license are made clear

Authors retain copyright of their work, with first publication rights (online and print) granted to Universe Scientific Publishing or the owner of the journal in question.