Photothermally Induced Alkyl Radicals and Pyroptosis Synergistically Inhibit Breast Tumor Growth

  • Yang Du First Affiliated Hospital, Dalian Medical University
  • Lili Niu First Affiliated Hospital, Dalian Medical University
  • Nannan Li First Affiliated Hospital, Dalian Medical University
  • Huishu Guo First Affiliated Hospital, Dalian Medical University
DOI: https://doi.org/10.18686/aem.v12i2.385
Keywords: Alkyl radical, Pyroptosis, Low-temperature photothermal therapy, Hydrogel, Breast cancer

Abstract

Photothermal therapy (PTT) is an emerging local tumor ablation technique with clinical translation potential. After the NIR-II laser irradiates the tumor, the photothermal agent Hu-Kaiwen ink (Ink) converts light energy into hyperthermia and maintains the temperature at 42-45°C, thus achieving a low-temperature photothermal therapy. Alkyl radicals can kill tumor cells by overcoming the hypoxic microenvironment of the tumor. The photothermal reaction can induce the conversion of alkyl radicals from 2,2′-azobis[2-(2-imidazolin-2-yl) propane] dihydrochloride (AIPH) and thus have a synergistic tumor inhibition effect. the DNA methyltransferase inhibitor decitabine (DCT) can induce pyroptosis and cause inflammation and immune response to achieve systemic immunity. In this way, a synergistic combination of photothermal, alkyl radicals and pyroptosis could be used to kill breast tumor cells. Sodium alginate (ALG) was used as a carrier to form a hydrogel structure, which can improve the stability and duration of action of the mixed drugs. The significant tumor growth inhibitory effect of composite hydrogels has been demonstrated in both in vitro and ex vivo studies.

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Published
2023-06-01
Issue
Vol 12, No 2 (2023)
Section
Original Research Article

Copyright (c) 2023 Yang Du, Lili Niu, Nannan Li, Huishu Guo

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