Novel Treatment Strategies for Periodontal Disease: Translational Research from Animal Models to Human Applications
Objective: Several emerging periodontal disease treatment strategies were emphasized, aiming to regulate the host immune response through host mediated therapy, which has shown good results in controlling inflammation and promoting periodontal tissue regeneration. Targeted antibacterial therapy, utilizing novel antibacterial drugs targeting periodontal pathogens, has been proven to be effective in reducing bacterial burden and improving clinical parameters. Methods: To conduct in-depth research on the pathogenesis of periodontal disease, discuss the interaction between periodontal health and overall condition, review current treatment methods, and explore promising translational research results, providing new methods for the management of periodontal disease. Results: Animal models play a key role in understanding the complex pathogenesis of periodontal disease and evaluating potential therapeutic interventions. These models allow for investigating disease mechanisms, evaluating treatment efficacy, and exploring safety profiles. By replicating various aspects of periodontal disease in animal models, such as inflammation, alveolar bone loss, and tissue regeneration, valuable insights into disease progression and treatment responses can be obtained. Conclusion: The research on the transformation from animal models to human applications is crucial for developing treatment strategies for periodontal disease. The integration of these emerging methods, including host regulated therapy, targeted antibacterial therapy, tissue engineering, and immunotherapy interventions, has the potential to fundamentally change clinical practice and improve patient prognosis. Further research, including carefully designed clinical trials, is necessary to verify the safety, effectiveness, and long-term effectiveness of these new treatment strategies.
Chapple ILC, Mealey BL, Van Dyke TE, et al. Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol. 2018;89 Suppl 1:S74-S84.
Taalab, Maha R., et al. "Intrapocket application of tea tree oil gel in the treatment of stage 2 periodontitis." BMC Oral Health 21.1 (2021): 239.
Li CN, et al. "Inhibitory effect of magnolol on alveolar bone resorption in rats with experimental periodontitis." Journal of Practical Stomatology . 34.03 (2018):341-344.
Haffajee AD, Socransky SS. Microbial etiological agents of destructive periodontal diseases. Periodontol 2000. 1994;5:78-111.
Holcombe, Lucy J., et al. "Early canine plaque biofilms: characterization of key bacterial interactions involved in initial colonization of enamel." PLoS One 9.12 (2014): e113744.
Marsh PD. Microbial ecology of dental plaque and its significance in health and disease. Adv Dent Res. 1994;8(2):263-271.
Berezow AB, Darveau RP. Microbial shift and periodontitis. Periodontol 2000. 2011;55(1):36-47.
Checchi, Vittorio, et al. "The role of matrix metalloproteinases in periodontal disease." International Journal of Environmental Research and Public Health 17.14 (2020): 4923.
Qasim, Syed Saad B., et al. "An evidence-based update on the molecular mechanisms underlying periodontal diseases." International journal of molecular sciences 21.11 (2020): 3829.
Preethanath, Reghunathan S., Wael I. Ibraheem, and Aiswarya Anil. "Pathogenesis of gingivitis." Oral Diseases (2020): 1-19.
Copyright (c) 2023 Der-Jeu Chen
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors submitting to USP journals agree to publish their manuscript under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0) where authors agree to allow third parties to share their work (copy, distribute, transmit) and to adapt it, under the condition that the authors are given credit, and that in the event of reuse or distribution, the terms of this license are made clear
Authors retain copyright of their work, with first publication rights (online and print) granted to Universe Scientific Publishing or the owner of the journal in question.