Novel Treatment Strategies for Periodontal Disease: Translational Research from Animal Models to Human Applications

  • Der-Jeu Chen National Chung Hsing University,
  • Cheng-Hung Lai Department of Veterinary Medicine, National Chung Hsing University
Keywords: Periodontal Disease; Translational Research; Animal Models; Novel Treatment Strategies; Clinical Outcomes


Objective: Several emerging periodontal disease treatment strategies were emphasized, aiming to regulate the host immune response through host mediated therapy, which has shown good results in controlling inflammation and promoting periodontal tissue regeneration. Targeted antibacterial therapy, utilizing novel antibacterial drugs targeting periodontal pathogens, has been proven to be effective in reducing bacterial burden and improving clinical parameters. Methods: To conduct in-depth research on the pathogenesis of periodontal disease, discuss the interaction between periodontal health and overall condition, review current treatment methods, and explore promising translational research results, providing new methods for the management of periodontal disease. Results: Animal models play a key role in understanding the complex pathogenesis of periodontal disease and evaluating potential therapeutic interventions. These models allow for investigating disease mechanisms, evaluating treatment efficacy, and exploring safety profiles. By replicating various aspects of periodontal disease in animal models, such as inflammation, alveolar bone loss, and tissue regeneration, valuable insights into disease progression and treatment responses can be obtained. Conclusion: The research on the transformation from animal models to human applications is crucial for developing treatment strategies for periodontal disease. The integration of these emerging methods, including host regulated therapy, targeted antibacterial therapy, tissue engineering, and immunotherapy interventions, has the potential to fundamentally change clinical practice and improve patient prognosis. Further research, including carefully designed clinical trials, is necessary to verify the safety, effectiveness, and long-term effectiveness of these new treatment strategies.


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Original Research Article