Research Progress of Platelets, Lymphocytes and Neutrophils in Sepsis

Anxin Chen, Dong Wan


Sepsis is a life-threatening organ dysfunction syndrome caused by the body's disregulated response to infection [1]. Platelets, lymphocytes and neutrophils are important cells in the immune response process of sepsis and play an important role in the progression of sepsis. Recently, research has found that platelet can inhibit bacteria, mediate inflammatory reaction process and secrete pro-inflammatory factors in addition to coagulation function. Lymphocytes act as adaptive immune cells, and low lymphocyte count can be a manifestation of immunosuppression. Neutrophils are important innate immune cells and represent the first barrier of immunity. Moreover, neutrophils, platelets and lymphocytes are common clinical indicators, which can be obtained in blood routine examination. As a new inflammatory index, Platelet-lymphocyte ratio and Neutral-lymphocyte ratio have gradually become the focus of the inflammatory index in the immune response process. In this paper, the value of platelet, lymphocytes and neutrophils in sepsis is reviewed.


Sepsis; Platelet; Lymphocyte; Neutrophil; Immune Response

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