Tumor‐Associated Macrophages in the Progression of Hepatocellular Carcinoma

Dingjie Liu, Yong Li


Hepatocellular carcinoma (HCC) contains many immune cell matrices, which constitute the tumor microenvironment (TME). Tumor-associated macrophages (TAM) are the main compartments of immune cell matrix in HCC, which play an important role in the pathogenesis of HCC, including immunosuppression, angiogenesis, tumor invasion and metastasis, and malignant transformation of HCC stem cells. At present, targeted TAM therapy for HCC has achieved promising results by eliminating existing TAMs, blocking the recruitment of TAMs, reprogramming TAMs polarization, regulating TAMs products and restoring TAMs phagocytosis. This review summarizes our understanding of TAMs and HCC, and discusses the role of TAMs in the development of HCC.


Tumor‐Associated Macrophages; Immunotherapy; Hepatocellular Carcinoma

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DOI: http://dx.doi.org/10.18686/aem.v12i2.359


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