Research progress of MicroRNA in podocytes autophagy in diabetic nephropathy

  • Ruixue Xie Department of Changzhi Medical College
  • Wengan Ji Department of Changzhi Medical College
  • Pengfei Fang Department of Changzhi Medical College
  • Feifei Wu Department of Changzhi Medical College
  • Haoyu Dong Department of Changzhi Medical College
Keywords: Diabetic Nephropathy, Podocytes, Microrna, Autophagy

Abstract

Diabetic nephropathy (DN) is one of the most common microvascular complications of diabetes, and is a kind of abnormal microangiopathy of kidney structure, function or clinical indicators caused by diabetes. Podocyte injury has been considered as a major contributor to the progression of diabetic nephropathy(DN). microRNA can participate in podocytes injury through autophagy.In this paper, the mechanism of microRNA involved in DN podocytes autophagy was reviewed to provide reference for the treatment of DN in the future.

References

[1] Fan Y, Lau ESH, Wu H, et al.Incidence of long-term diabetes complications and mortality in youth-onset type 2 diabetes: A systematic review. Diabetes Res Clin Pract. 2022 Sep;191:110030.

[2] Lay AC, Hale LJ, Stowell-Connolly H, et al. IGFBP-1 expression is reduced in human type 2 diabetic glomeruli and modulates β1-integrin/FAK signalling in human podocytes. Diabetologia. 2021 Jul;64(7):1690-1702.

[3] Ichimiya T, Yamakawa T, Hirano T, et al.Autophagy and Autophagy-Related Diseases: A Review. Int J Mol Sci. 2020 Nov 26;21(23):8974.

[4] Zhang Y, Chang B, Zhang J,et al. LncRNA SOX2OT alleviates the high glucose-induced podocytes injury through autophagy induction by the miR-9/SIRT1 axis. Exp Mol Pathol. 2019 Oct;110:104283.

[5] Hong Q, Zhang L, Das B, et al.Increased podocyte Sirtuin-1 function attenuates diabetic kidney injury. Kidney Int. 2018 Jun;93(6):1330-1343.

[6] Platt C, Coward RJ. Peroxisome proliferator activating receptor-γ and the podocyte. Nephrol Dial Transplant. 2017 Mar 1;32(3):423-433.

[7] Li F, Dai B, Ni X. Long non-coding RNA cancer susceptibility candidate 2 (CASC2) alleviates the high glucose-induced injury of CIHP-1 cells via regulating miR-9-5p/PPARγ axis in diabetes nephropathy. Diabetol Metab Syndr. 2020 Aug 6;12:68.

[8] Dey N, Das F, Mariappan MM, et al.MicroRNA-21 orchestrates high glucose-induced signals to TOR complex 1, resulting in renal cell pathology in diabetes. J Biol Chem. 2011 Jul 22;286(29):25586-25603.

[9] Xu L, Fan Q, Wang X, et al.Ursolic acid improves podocyte injury caused by high glucose. Nephrol Dial Transplant. 2017 Aug 1;32(8):1285-1293.

[10] Luo A, Yan H, Liang J, et al. MicroRNA-21 regulates hepatic glucose metabolism by targeting FOXO1. Gene. 2017 Sep 5;627:194-201.

[11] Liang Y, Liu H, Zhu J,et al.Inhibition of p53/miR-34a/SIRT1 axis ameliorates podocyte injury in diabetic nephropathy. Biochem Biophys Res Commun. 2021 Jun 25;559:48-55.

[12] Ding X, Jing N, Shen A, et al.MiR-21-5p in macrophage-derived extracellular vesicles affects podocyte pyroptosis in diabetic nephropathy by regulating A20. J Endocrinol Invest. 2021 Jun;44(6):1175-1184.
Published
2023-03-02
Section
Original Research Article