Mitochondria-Derived Peptides in Age-Related Diseases: A Review
Keywords:
Mitochondria-Derived Peptides, Oxidative Stress, Genome, Mutation, Cell Aging
Abstract
Mitochondrial—derived peptides (MDPs) are new kinds of peptides, which are small open reading frames in circular mitochondrial DNA that encode a variety of microproteins, including humanin(HN), SHLPs 1-6, and MOTS-c. It is found that it can regulate mitochondrial bioenergy and mitochondrial metabolism, and has many biological effects such as helping to maintain mitochondrial function and cell viability under stress conditions, giving play to cell protection and improving metabolic markers.In this paper, we review recent research progress in MDPs, examines the biological effects of MDPs and focus on the role of MDPs in ARDs, including mechanism of action and therapeutic potential.
References
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[24] Yaşar E, Çakmak T, Bayramoğlu A, et al. MOTS-c as a predictor of coronary lesions and complexity in patients with stable coronary artery disease [J]. European review for medical and pharmacological sciences, 2022, 26(16): 5676-82.
[25] Cai H, Cao P, Sun W, et al. Circulating humanin is lower in coronary artery disease and is a prognostic biomarker for major cardiac events in humans [J]. Biochimica et biophysica acta General subjects, 2022, 1866(1): 130010.
[26] Zárate SC, Traetta ME, Codagnone MG, et al. Humanin, a Mitochondrial- Derived Peptide Released by Astrocytes, Prevents Synapse Loss in Hippocampal Neurons [J]. Frontiers in aging neuroscience, 2019, 11(123.
[27] Ikegawa N, Kozuka A, Morita N, et al. Humanin derivative, HNG, enhances neurotransmitter release [J]. Biochimica et biophysica acta General subjects, 2022, 1866(10): 130204.
[2] Wu Y, Sun L, Zhuang Z, et al. Mitochondrial-Derived Peptides in Diabetes and Its Complications [J]. Frontiers in endocrinology, 2021, 12(808120.
[3] Chen G, Kroemer G, Kepp O. Mitophagy: An Emerging Role in Aging and Age-Associated Diseases [J]. Frontiers in cell and developmental biology, 2020, 8(200.
[4] Natarajan V, Chawla R, Mah T, et al. Mitochondrial Dysfunction in Age-Related Metabolic Disorders [J]. Proteomics, 2020, 20(5-6): e1800404.
[5] Lee C, Yen K, Cohen P. Humanin: a harbinger of mitochondrial-derived peptides? [J]. Trends in endocrinology and metabolism: TEM, 2013, 24(5): 222-8.
[6] Qin Q, Delrio S, Wan J, et al. Downregulation of circulating MOTS-c levels in patients with coronary endothelial dysfunction [J]. International journal of cardiology, 2018, 254(23-7.
[7] Du C, Zhang C, Wu W, et al. Circulating MOTS-c levels are decreased in obese male children and adolescents and associated with insulin resistance [J]. Pediatric diabetes, 2018.
[8] Zaman F, Zhao Y, Celvin B, et al. Humanin is a novel regulator of Hedgehog signaling and prevents glucocorticoid-induced bone growth impairment [J]. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, 33(4): 4962-74.
[9] Zuccato CF, Asad AS, Nicola Candia AJ, et al. Mitochondrial-derived peptide humanin as therapeutic target in cancer and degenerative diseases [J]. Expert opinion on therapeutic targets, 2019, 23(2): 117-26.
[10] Hashimoto Y, Ito Y, Niikura T, et al. Mechanisms of neuroprotection by a novel rescue factor humanin from Swedish mutant amyloid precursor protein [J]. Biochemical and biophysical research communications, 2001, 283(2): 460-8.
[11] Conte M, Martucci M, Chiariello A, et al. Mitochondria, immunosenescence and inflammaging: a role for mitokines? [J]. Seminars in immunopathology, 2020, 42(5): 607-17.
[12] Yen K, Mehta HH, Kim SJ, et al. The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan [J]. Aging, 2020, 12(12): 11185-99.
[13] Lee C, Zeng J, Drew BG, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance [J]. Cell metabolism, 2015, 21(3): 443-54.
[14] Kim KH, Son JM, Benayoun BA, et al. The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress [J]. Cell metabolism, 2018, 28(3): 516-24.e7.
[15] Kim SJ, Xiao J, Wan J, et al. Mitochondrially derived peptides as novel regulators of metabolism [J]. The Journal of physiology, 2017, 595(21): 6613-21.
[16] Mohtashami Z, Singh MK, Salimiaghdam N, et al. MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases [J]. International journal of molecular sciences, 2022, 23(19).
[17] Cobb LJ, Lee C, Xiao J, et al. Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers [J]. Aging, 2016, 8(4): 796-809.
[18] Sada K, Nishikawa T, Kukidome D, et al. Hyperglycemia Induces Cellular Hypoxia through Production of Mitochondrial ROS Followed by Suppression of Aquaporin-1 [J]. PloS one, 2016, 11(7): e0158619.
[19] Sequeira I R, Woodhead J S T, Chan A, et al. Plasma mitochondrial derived peptides MOTS-c and SHLP2 positively associate with android and liver fat in people without diabetes [J]. Biochimica et biophysica acta General subjects, 2021, 1865(11): 129991.
[20] Yang B, Yu Q, Chang B, et al. MOTS-c interacts synergistically with exercise intervention to regulate PGC-1α expression, attenuate insulin resistance and enhance glucose metabolism in mice via AMPK signaling pathway [J]. Biochimica et biophysica acta Molecular basis of disease, 2021, 1867(6): 166126.
[21] Yin Y, Pan Y, He J, et al. The mitochondrial-derived peptide MOTS-c relieves hyperglycemia and insulin resistance in gestational diabetes mellitus [J]. Pharmacological research, 2022, 175(105987.
[22] Shen M Y, Wang M, Liu Z, et al. [Gly14]-Humanin Ameliorates High Glucose-Induced Apoptosis by Inhibiting the Expression of MicroRNA-155 in Endothelial Microparticles [J]. Diabetes, metabolic syndrome and obesity : targets and therapy, 2021, 14(2335-47.
[23] Gong Z, Goetzman E, Muzumdar RH. Cardio-protective role of Humanin in myocardial ischemia-reperfusion [J]. Biochimica et biophysica acta General subjects, 2022, 1866(2): 130066.
[24] Yaşar E, Çakmak T, Bayramoğlu A, et al. MOTS-c as a predictor of coronary lesions and complexity in patients with stable coronary artery disease [J]. European review for medical and pharmacological sciences, 2022, 26(16): 5676-82.
[25] Cai H, Cao P, Sun W, et al. Circulating humanin is lower in coronary artery disease and is a prognostic biomarker for major cardiac events in humans [J]. Biochimica et biophysica acta General subjects, 2022, 1866(1): 130010.
[26] Zárate SC, Traetta ME, Codagnone MG, et al. Humanin, a Mitochondrial- Derived Peptide Released by Astrocytes, Prevents Synapse Loss in Hippocampal Neurons [J]. Frontiers in aging neuroscience, 2019, 11(123.
[27] Ikegawa N, Kozuka A, Morita N, et al. Humanin derivative, HNG, enhances neurotransmitter release [J]. Biochimica et biophysica acta General subjects, 2022, 1866(10): 130204.
Published
2023-03-21
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Original Research Article
Copyright (c) 2023 Chuying Zhao
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