Mitochondria-Derived Peptides in Age-Related Diseases: A Review

  • Chuying Zhao the First Affiliated Hospital of Chongqing Medical University
  • Ying Li the First Affiliated Hospital of Chongqing Medical University
Keywords: Mitochondria-Derived Peptides, Oxidative Stress, Genome, Mutation, Cell Aging


Mitochondrial—derived peptides (MDPs) are new kinds of peptides, which are small open reading frames in circular mitochondrial DNA that encode a variety of microproteins, including humanin(HN), SHLPs 1-6, and MOTS-c. It is found that it can regulate mitochondrial bioenergy and mitochondrial metabolism, and has many biological effects such as helping to maintain mitochondrial function and cell viability under stress conditions, giving play to cell protection and improving metabolic markers.In this paper, we review recent research progress in MDPs, examines the biological effects of MDPs and focus on the role of MDPs in ARDs, including mechanism of action and therapeutic potential.


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Original Research Article