Research Progress of Abnormal Expression of LKB1/STK111 in Non-Small Cell Lung Cancer

  • Fengmei Cao Shaanxi University of Chinese Medicine
  • Jiayun Liu Xijing Hospital, Forth Military Medical University
Keywords: LKB1/STK111, Non Small Cell Lung Cancer, Tumor Suppressive Mechanism, Prognosis, Treatment


Non small cell lung cancer (NSCLC) is a kind of malignant tumor originated from bronchial mucosa, bronchial glands and alveolar epithelium. It has become the main cause of death of malignant tumors in our population. STK11 is a common tumor suppressor gene, its encoded protein liver kinase B1 (LKB1) is an essential serine / threonine protein kinase. LKB1/STK111 inhibits the occurrence and development of tumors through a variety of mechanisms and plays a key regulatory role in malignant tumors. The increased risk of cancer development is also associated with the absence of STK11. More and more studies have found that the abnormal expression of LKB1/STK111 will affect the occurrence and development of lung cancer, especially in NSCLC. This paper reviews the tumor suppressive mechanism of LKB1/STK111 in the occurrence and development of NSCLC, its relationship with NSCLC, and the prognosis and treatment.


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Original Research Article