Investigation and Fabrication of Micromotors for Biomedical Applications

  • Yu'ang Zhang Jinan University
Keywords: Micromotor, Bioengineering, Tissue Engineering, Hydrogel


The research of micromotors have received extensive attention in recent years, and their iconic feature is the ability to utilize external energy to achieve autonomous motion then carry out various tasks. Micromotor for biological applications is a common type of micromotors, this specific type of micromotor is capable to be applied to drug delivery system and transportation of cells. The content of this article is to introduce examples, potential, and current problems of micromotors based on hydrogels or other kind of environment-friendly materials for cell culture and drug delivery, and to further explore the effects of hydrogels and micromotors on cells and drugs. In addition, methods and steps of the preparation of a four-sided, dual-power Sodium Alginate (SA) hydrogel micromotor is demonstrated and explicitized, the micromotor’s ability to achieve independent movement and its potential applications are also explored.


[1] Sun M, Fan X, Meng X, et al, Magnetic biohybrid micromotors with high maneuverability for efficient drug loading and targeted drug delivery, Nanoscale, 2019, 11, 18382-18392.

[2] Balasubramanian S, Kagan D, Jack Hu CM, et al. Micromachine‐enabled capture and isolation of cancer cells in complex media[J]. Angewandte Chemie, 2011, 123(18): 4247-4250.

[3] Yu Y, Guo J, Wang Y, et al. Bioinspired helical micromotors as dynamic cell microcarriers[J]. ACS applied materials & interfaces, 2020, 12(14): 16097-16103.

[4] Tang G, Chen L, Lian L, et al. Designable dual-power micromotors fabricated from a biocompatible gas-shearing strategy[J]. Chemical Engineering Journal, 2021, 407: 127187.
Original Research Article