Treating Cartilage Injuries in Young Patients

  • Feier Ma Xi’an Physical Education University
Keywords: Cartilage Injury, Arthroscopic Debridement, MACI, OCA, OAT

Abstract

Young people tend to suffer from cartilage injuries caused by extraneous trauma. There are many treatments for cartilage injuries. This article recommends treatments for different cartilage injuries targeted towards young patients. For young patients with mild or asymptomatic symptoms without cartilage displacement, this article recommends mandatory conservative treatment for young patients. Depending on the recovery condition of conservative treatment, the surgeon can subsequently plan for surgical treatment. Depending on lesion size, this article recommends the following operations. For lesions less than 1 cm2, arthroscopic debridement is recommended. For lesions between 1 and 4 cm2, MACI is recommended. For lesions larger than 4 cm2, OCA is recommended as a priority. If OCA is not feasible, OAT can be considered.

References

[1] Aaron, R. K., Skolnick, A. H., Reinert, S. E., & Ciombor, D. M. (2006). Arthroscopic Débridement for Osteoarthritis of the Knee. JBJS, 88(5).

[2] Abolghasemian, M., León, S., Lee, P. T. H., Safir, O., Backstein, D., Gross, A. E., & Kuzyk, P. R. T. (2019). Long-Term Results of Treating Large Posttraumatic Tibial Plateau Lesions with Fresh Osteochondral Allograft Transplantation. JBJS, 101(12).

[3] Alexander, P. G., Song, Y., Taboas, J. M., Chen, F. H., Melvin, G. M., Manner, P. A., & Tuan, R. S. (2013). Development of a Spring-Loaded Impact Device to Deliver Injurious Mechanical Impacts to the Articular Cartilage Surface. Cartilage, 4(1), 52-62.

[4] Anderson, D. D., Van Hofwegen, C., Marsh, J. L., & Brown, T. D. (2011). Is elevated contact stress predictive of post-traumatic osteoarthritis for imprecisely reduced tibial plafond fractures? Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 29(1), 33-39.

[5] Andrade, R., Vasta, S., Pereira, R., Pereira, H., Papalia, R., Karahan, M., Oliveira, J. M., Reis, R. L., & Espregueira-Mendes, J. (2016). Knee donor-site morbidity after mosaicplasty - a systematic review. Journal of experimental orthopaedics, 3(1), 31-31.

[6] Andriolo, L., Di Martino, A., Altamura, S. A., Boffa, A., Poggi, A., Busacca, M., Zaffagnini, S., & Filardo, G. (2021). Matrix-assisted chondrocyte transplantation with bone grafting for knee osteochondritis dissecans: stable results at 12 years. Knee Surgery, Sports Traumatology, Arthroscopy, 29(6), 1830-1840.

[7] Badekas, T., Takvorian, M., & Souras, N. (2013). Treatment principles for osteochondral lesions in foot and ankle. International orthopaedics, 37(9), 1697-1706.

[8] Baltzer, A. W. A., Ostapczuk, M. S., Terheiden, H. P., & Merk, H. R. (2016). Good short- to medium-term results after osteochondral autograft transplantation (OAT) in middle-aged patients with focal, non-traumatic osteochondral lesions of the knee. Orthopaedics & Traumatology: Surgery & Research, 102(7), 879-884.

[9] Barakat, A. S., Ibrahim, N. M., Elghobashy, O., Sultan, A. M., & Abdel-Kader, K. F. M. (2019). Prevention of post-traumatic osteoarthritis after intra-articular knee fractures using hyaluronic acid: a randomized prospective pilot study. International orthopaedics, 43(11), 2437-2445.

[10] Bisicchia, S., Rosso, F., & Amendola, A. (2014). Osteochondral allograft of the talus. The Iowa orthopaedic journal, 34, 30-37.
[11] Bonasia, D., Rossi, R., & Bardelli, A. (2005). Tibial plateau fractures. A review of classifications. Minerva Ortopedica e Traumatologica, 56(5), 457.

[12] Buckwalter, J. A. (2012). The role of mechanical forces in the initiation and progression of osteoarthritis. HSS journal : the musculoskeletal journal of Hospital for Special Surgery, 8(1), 37-38.

[13] Centeno, C. J., Al-Sayegh, H., Bashir, J., Goodyear, S., & Freeman, M. D. (2015). A dose response analysis of a specific bone marrow concentrate treatment protocol for knee osteoarthritis. BMC musculoskeletal disorders, 16, 258-258.

[14] Chimutengwende-Gordon, M., Ahmad, M. A., Bentley, G., Brammah, J., Carrington, R., Miles, J., & Donaldson, J. (2021). Stem cell transplantation for the treatment of osteochondral defects of the knee: Operative technique for a single-stage transplantation procedure using bone marrow-derived mesenchymal stem cells. The Knee, 28, 400-409.

[15] Chu, CH., Chen, IH., Yang, KC., & Wang, CC. (2020). Midterm Results of Fresh-Frozen Osteochondral Allografting for Osteochondral Lesions of the Talus. Foot & Ankle International, 42(1), 8-16.

[16] Cinats, D., Miller, S., Abusara, Z., Heard, S. M., Hutchison, C., Schachar, N., & Timmermann, S. (2021). Evolution of a Novel Tissue Preservation Protocol to Optimize Osteochondral Transplantation Outcomes. Cartilage, 12(1), 31-41.

[17] Cohen, A. P., Redden, J. F., & Stanley, D. (2000). Treatment of osteoarthritis of the elbow: A comparison of open and arthroscopic debridement. Arthroscopy: The Journal of Arthroscopic & Related Surgery, 16(7), 701-706.

[18] Crossley, K. M., Vicenzino, B., Lentzos, J., Schache, A. G., Pandy, M. G., Ozturk, H., & Hinman, R. S. (2015). Exercise, education, manual-therapy and taping compared to education for patellofemoral osteoarthritis: a blinded, randomised clinical trial. Osteoarthritis and Cartilage, 23(9), 1457-1464.

[19] Dantas, L. O., Moreira, R. d. F. C., Norde, F. M., Mendes Silva Serrao, P. R., Alburquerque-Sendín, F., & Salvini, T. F. (2019). The effects of cryotherapy on pain and function in individuals with knee osteoarthritis: a systematic review of randomized controlled trials. Clinical Rehabilitation, 33(8), 1310-1319.

[20] Daud, A., Safir, O. A., Gross, A. E., & Kuzyk, P. R. T. (2021). Outcomes of Bulk Fresh Osteochondral Allografts for Cartilage Restoration in the Knee. J Bone Joint Surg Am, 103(22), 2115-2125.

[21] De Schepper, A. M., De Beuckeleer, L., Vandevenne, J., & Somville, J. (2000). Magnetic resonance imaging of soft tissue tumors. European Radiology, 10(2), 213-223.

[22] Dervin, G. F., Stiell, I. G., Rody, K., & Grabowski, J. (2003). Effect of Arthroscopic Débridement for Osteoarthritis of the Knee on Health-Related Quality of Life*. JBJS, 85(1).

[23] Di Martino, A., Perdisa, F., Filardo, G., Busacca, M., Kon, E., Marcacci, M., & Zaffagnini, S. (2021). Cell-Free Biomimetic Osteochondral Scaffold for the Treatment of Knee Lesions: Clinical and Imaging Results at 10-Year Follow-up. The American Journal of Sports Medicine, 49(10), 2645-2650.

[24] Di Martino, A., Silva, S., Andriolo, L., Merli, G., Reale, D., Zaffagnini, S., & Filardo, G. (2021). Osteochondral autograft transplantation versus autologous bone-cartilage paste grafting for the treatment of knee osteochondritis dissecans. International orthopaedics, 45(2), 453-461.

[25] Dong, Y., Zhang, P., & Fan, L. (2021). Recognition of Factors of Postoperative Complications of Knee Osteoarthritis Patients and Comprehensive Nursing Intervention. Computational and mathematical methods in medicine, 2021, 1840613-1840613.

[26] Drobnič, M., Kolar, M., Verdonk, P., Vannini, F., Robinson, D., Altschuler, N., Shabshin, N., & Kon, E. (2021). Complex Osteochondral Lesions of the Talus Treated With a Novel Bi-Phasic Aragonite-based Implant. The Journal of Foot and Ankle Surgery, 60(2), 391-395.

[27] Edwards, P. K., Ackland, T., & Ebert, J. R. (2013). Clinical Rehabilitation Guidelines for Matrix-Induced Autologous Chondrocyte Implantation on the Tibiofemoral Joint. Journal of Orthopaedic & Sports Physical Therapy, 44(2), 102-119.

[28] Eichman, E. A., Harris, B. T., & Burrus, M. T. (2021). Management of bilateral osteochondritis dissecans of the trochlea in a skeletally immature patient. BMJ Case Reports, 14(1), e239849.

[29] Fayyad, D. M., Abdelsalam, N., & Hashem, N. (2020). Cryotherapy: A New Paradigm of Treatment in Endodontics. Journal of Endodontics, 46(7), 936-942.

[30] Gu, Y., Yang, D., Huang, Q., Yang, W., & Liu, H. (2018). Robust EMG pattern recognition in the presence of confounding factors: features, classifiers and adaptive learning. Expert Systems with Applications, 96, 208-217.

[31] Hamblin, T., Curtis, S. H., D’Astous, J., & Aoki, S. K. (2010). Childhood Obesity and Low-Velocity Knee Dislocation in a Fifteen-Year-Old Girl: A Case Report. JBJS, 92(12).

[32] Harris, J. D., Siston, R. A., Pan, X., & Flanigan, D. C. (2010). Autologous chondrocyte implantation: a systematic review. The Journal of bone and joint surgery. American volume, 92(12), 2220-2233.

[33] Ibarra, C., Villalobos, E., Madrazo-Ibarra, A., et al (2021). Arthroscopic Matrix- Assisted Autologous Chondrocyte Transplantation Versus Microfracture: A 6-Year Follow-up of a Prospective Randomized Trial. The American Journal of Sports Medicine, 49(8), 2165-2176.

[34] Kon, E., Di Matteo, B., Verdonk, P., et al (2021). Aragonite-Based Scaffold for the Treatment of Joint Surface Lesions in Mild to Moderate Osteoarthritic Knees: Results of a 2-Year Multicenter Prospective Study. The American Journal of Sports Medicine, 49(3), 588-598.

[35] Körner, D., Gonser, C. E., Döbele, S., Konrads, C., Springer, F., & Keller, G. (2021a). Matrix-associated autologous chondrocyte implantation with autologous bone grafting of osteochondral lesions of the talus in adolescents: patient-reported outcomes with a median follow-up of 6 years. Journal of Orthopaedic Surgery and Research, 16(1), 243-243.

[36] Körner, D., Gonser, C. E., Döbele, S., Konrads, C., Springer, F., & Keller, G. (2021b). Re-operation rate after surgical treatment of osteochondral lesions of the talus in paediatric and adolescent patients. Journal of Orthopaedic Surgery and Research, 16(1), 187-187.

[37] Krych, A. J., Pareek, A., King, A. H., Johnson, N. R., Stuart, M. J., & Williams, R. J. (2017). Return to sport after the surgical management of articular cartilage lesions in the knee: a meta-analysis. Knee Surgery, Sports Traumatology, Arthroscopy, 25(10), 3186-3196.

[38] Lamplot, J. D., Schafer, K. A., & Matava, M. J. (2018). Treatment of Failed Articular Cartilage Reconstructive Procedures of the Knee: A Systematic Review. Orthopaedic Journal of Sports Medicine, 6(3), 2325967118761871.

[39] Lattermann, C., & Romine, S. E. (2009). Osteochondral Allografts: State of the Art. Clinics in Sports Medicine, 28(2), 285-301.

[40] Lieberthal, J., Sambamurthy, N., & Scanzello, C. R. (2015). Inflammation in joint injury and post-traumatic osteoarthritis. Osteoarthritis and Cartilage, 23(11), 1825-1834.

[41] Liu, HC., Liu, TST., Liu, YL., et al (2021). Atelocollagen-Embedded Chondrocyte Precursors as a Treatment for Grade-4 Cartilage Defects of the Femoral Condyle: A Case Series with up to 9-Year Follow-Up. Biomolecules, 11(7), 942.

[42] Lolli, A., Sivasubramaniyan, K., Vainieri, M. L., Oieni, J., Kops, N., Yayon, A., & van Osch, G. J. V. M. (2019). Hydrogel-based delivery of antimiR-221 enhances cartilage regeneration by endogenous cells. Journal of Controlled Release, 309, 220-230.

[43] Lopa, S., Colombini, A., Moretti, M., & de Girolamo, L. (2019). Injective mesenchymal stem cell-based treatments for knee osteoarthritis: from mechanisms of action to current clinical evidences. Knee surgery, sports traumatology, arthroscopy: official journal of the ESSKA, 27(6), 2003-2020.

[44] López-Alcorocho, J. M., Guillén-Vicente, I., Rodríguez-Iñigo, E., Navarro, R., Caballero-Santos, R., Guillén-Vicente, M., Casqueiro, M., Fernández-Jaén, T. F., Sanz, F., Arauz, S., Abelow, S., & Guillén-García, P. (2021). High-Density Autologous Chondrocyte Implantation as Treatment for Ankle Osteochondral Defects. Cartilage, 12(3), 307-319.

[45] Magnussen, R. A., Dunn, W. R., Carey, J. L., & Spindler, K. P. (2008). Treatment of focal articular cartilage defects in the knee: a systematic review. Clinical orthopaedics and related research, 466(4), 952-962.

[46] Mardones, R., Giai Via, A., Pipino, G., Jofre, C. M., Muñoz, S., Narvaez, E., & Maffulli, N. (2020). BM-MSCs differentiated to chondrocytes for treatment of full-thickness cartilage defect of the knee. Journal of Orthopaedic Surgery and Research, 15(1), 455-455.

[47] Merritt, G., Epstein, J., Roland, D., & Bell, D. (2021). Fresh osteochondral allograft transplantation (FOCAT) for definitive management of a 198 square millimeter osteochondral lesion of the talus (OLT): A case report. The Foot, 46, 101639.

[48] Niethammer, T. R., Altmann, D., Holzgruber, M., Goller, S., Fischer, A., & Müller, P. E. (2021). Third generation autologous chondrocyte implantation is a good treatment option for athletic persons. Knee Surgery, Sports Traumatology, Arthroscopy, 29(4), 1215-1223.

[49] Occhetta, P., Stüdle, C., Barbero, A., & Martin, I. (2016). Learn, simplify and implement: developmental re-engineering strategies for cartilage repai. Swiss Med Wkly, 146, w14346.

[50] Prakash, D., & Learmonth, D. (2002). Natural progression of osteo-chondral defect in the femoral condyle. The Knee, 9(1), 7-10.

[51] Puntel, G. O., Carvalho, N. R., Dobrachinski, F., Salgueiro, A. C. F., Puntel, R. L., Folmer, V., Barbosa, N. B. V., Royes, L. F. F., Rocha, J. B. T., & Soares, F. A. A. (2013). Cryotherapy reduces skeletal muscle damage after ischemia/reperfusion in rats. Journal of anatomy, 222(2), 223-230.

[52] Rahusen, F. T. G., Brinkman, J. M., & Eygendaal, D. (2006). Results of arthroscopic debridement for osteochondritis dissecans of the elbow. British journal of sports medicine, 40(12), 966-969.

[53] Reilingh, M. L., Kerkhoffs, G. M. M. J., Telkamp, C. J. A., Struijs, P. A. A., & van Dijk, C. N. (2014). Treatment of osteochondral defects of the talus in children. Knee Surgery, Sports Traumatology, Arthroscopy, 22(9), 2243-2249.

[54] Richter, D. L., Tanksley, J. A., & Miller, M. D. (2016). Osteochondral Autograft Transplantation: A Review of the Surgical Technique and Outcomes. Sports Medicine and Arthroscopy Review, 24(2).

[55] Riegger, J., Zimmermann, M., Joos, H., Kappe, T., & Brenner, R. E. (2018). Hypothermia Promotes Cell-Protective and Chondroprotective Effects After Blunt Cartilage Trauma. The American Journal of Sports Medicine, 46(2), 420-430.

[56] Salzmann, G. M., Niemeyer, P., Hochrein, A., Stoddart, M. J., & Angele, P. (2018). Articular Cartilage Repair of the Knee in Children and Adolescents. Orthopaedic Journal of Sports Medicine, 6(3), 2325967118760190.

[57] Savage-Elliott, I., Ross, K. A., Smyth, N. A., Murawski, C. D., & Kennedy, J. G. (2014). Osteochondral lesions of the talus: a current concepts review and evidence-based treatment paradigm. Foot Ankle Spec, 7(5), 414-422.

[58] Shetty, A. A., Kim, S. J., Ahmed, S., Trattnig, S., Kim, S. A., & Jang, H. J. (2018). A cost-effective cell- and matrix-based minimally invasive single-stage chondroregenerative technique developed with validated vertical translation methodology. Annals of the Royal College of Surgeons of England, 100(3), 240-246.

[59] Skou, ST., Lind, M., Hölmich, P., Jensen, H. P., Jensen, C., Afzal, M., Jørgensen, U., & Thorlund, J. B. (2017). Study protocol for a randomised controlled trial of meniscal surgery compared with exercise and patient education for treatment of meniscal tears in young adults. BMJ open, 7(8), e017436-e017436.

[60] Thompson, M. J., & Roukis, T. S. (2020). Osteochondral Lesions of the Talar Dome. Clinics in Podiatric Medicine and Surgery, 37(3), 533-551.

[61] Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007). Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nature Cell Biology, 9(6), 654-659.

[62] Versier, G., & Dubrana, F. (2011). Treatment of knee cartilage defect in 2010. Orthopaedics & Traumatology: Surgery & Research, 97(8, Supplement), S140-S153.

[63] Wang, B., Xi, Z., Liang, Q., Mi, K., & Feng, Z. (2017). Matrix-induced autologous chondrocyte implantation for treatment of femoral trochlea cartilage injury. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, 31(1), 98-104.

[64] Weinstein, D. M., Bucchieri, J. S., Pollock, R. G., Flatow, E. L., & Bigliani, L. U. (2000). Arthroscopic debridement of the shoulder for osteoarthritis. Arthroscopy: The Journal of Arthroscopic & Related Surgery, 16(5), 471-476.

[65] Wu, X., Wang, Y., Xiao, Y., Crawford, R., Mao, X., & Prasadam, I. (2019). Extracellular vesicles: Potential role in osteoarthritis regenerative medicine. Journal of orthopaedic translation, 21, 73-80.

[66] Xia, Q., Wang, Q., Lin, F., & Wang, J. (2021). miR-125a-5p-abundant exosomes derived from mesenchymal stem cells suppress chondrocyte degeneration via targeting E2F2 in traumatic osteoarthritis. Bioengineered, 12(2), 11225-11238.

[67] Zhang, Y., Liang, J.-Q., Wen, X.-D., Liu, P.-L., Lu, J., & Zhao, H.-M. (2022). Triplane osteotomy combined with talar non-weight-bearing area autologous osteochondral transplantation for osteochondral lesions of the talus. BMC musculoskeletal disorders, 23(1), 79-79.

[68] Zhou, Y., Li, H., Xiang, D., Shao, J., Fu, Q., Han, Y., Zhu, J., Chen, Y., & Qian, Q. (2021). The clinical efficacy of arthroscopic therapy with knee infrapatellar fat pad cell concentrates in treating knee cartilage lesion: a prospective, randomized, and controlled study. Journal of Orthopaedic Surgery and Research, 16(1), 87-87.
Published
2023-03-02
Section
Original Research Article