Changes of Acylating Stimulating Protein (ASP) and Blood Lipid in Patients with Acute Myocardial Infarction

  • Honglei Jiang Department of Cardiology, Shandong Second Provincial General Hospital
  • Bei Tan Department of Cardiology, Shandong Second Provincial General Hospital
  • Yang Ge Department of Cardiology, Shandong Second Provincial General Hospital
  • Ying Liu Department of Cardiology, Shandong Second Provincial General Hospital
  • Xiaoyan Lu Department of Cardiology, Shandong Second Provincial General Hospital
  • Chunlin Cao Department of Cardiology, Shandong Second Provincial General Hospital
  • Shujing Yang Department of Cardiology, Shandong Second Provincial General Hospital
DOI: https://doi.org/10.18686/aem.v11i4.265
Keywords: Acute Myocardial Infarction, Acylating Stimulating Protein, Blood Lipid Introduction

Abstract

Objective: To study the changes of acylating stimulating protein (ASP) and blood lipid in patients with acute myocardial infarction. Method: There were three groups,25 cases of acute myocardial infarction patients (acute myocardial infarction group), 32 cases of coronary heart disease patients without myocardial infarction (CHD group) and 30 cases of healthy people (control group). They respectively detected the ASP, low density lipoprotein cholesterol (LDL-C), triglyceride (TG), total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C), and analyzed the correlation between them. Results: (1) ASP, TG, TC and LDL-C of acute myocardial infarction group and coronary heart disease group were significantly higher than those of control group, while HDL-C was lower than control group, the difference was statistically significant (P < 0.05). (2) TG in coronary heart disease group was higher than that in acute myocardial infarction group, while ASP, TC, LDL-C and HDL-C had no significant difference. Conclusion: ASP and blood lipid are risk factors of CHD, ASP can be used as risk index of CHD. There was no significant difference in plasma ASP between patients with acute myocardial infarction and patients with coronary heart disease without myocardial infarction. ASP cannot be used as a surrogate marker of acute myocardial infarction.

References

[1] Théroux P, Martel C. Complement activity and pharmacological inhibition in cardiovascular disease. Can J Cardiol. 2006;22(Suppl B):18B–24B.

[2] Liu J, Hu XF, Lu HL, et al. Effects of acylating stimulating protein on glycolipid metabolism in 3T3-L1 adipocytes[J] .Journal of Medical Research., 2018, 47(2): 69-73.

[3] Yasuda M, Takeuchi K, Hiruma M, et al. The complement system in ischemic heart disease[J]. Circulation, 1990,81(1):156-163.

[4] Al-Kuraishy H, Al-Gareeb A. Acylation-stimulating protein is a surrogate biomarker for acute myocardial infarction: Role of statins[J]. Journal of Laboratory Physicians,2017,9(3).

[5] Jin XX, Hu DY, Gao MM, et.al. Comparison of lipid changes between unstable angina pectoris and acute myocardial infarction[J]. Journal of Continuing Education of Physicians.1999, 22(1):26-27.

[6] Magnusson B, Asp L, Boström P, Ruiz M, Stillemark-Billton P, Lindén D, et al. Adipocyte differentiation-related protein promotes fatty acid storage in cytosolic triglycerides and inhibits secretion of very low-density lipoproteins. Arterioscler Thromb Vasc Biol. 2006;26:1566–71.

[7] Sivakumar K, Bari MF, Adaikalakoteswari A, Guller S, Weickert MO, Randeva HS, et al. Elevated fetal adipsin/acylation-stimulating protein (ASP) in obese pregnancy: Novel placental secretion via Hofbauer cells. J Clin Endocrinol Metab. 2013;98:4113–22.

[8] Nawaz H, Comerford BP, Njike VY, et al. Repeated Serum Lipid Measurements During the Peri-Hospitalization Period[J]. American Journal of Cardiology, 2006, 98(10):1379-1382.

[9] RK AÄ­dyraliev, MT BeÄ­shenkulov, Murataliev T M, et al. [Analysis of the amount of plasma cholesterol and triglycerides in patients with coronary heart disease].[J]. Klinicheskaia Laboratornaia Diagnostika, 2006(11):34.

[10] Zhao WQ, Wang J, Xie HZ, et al. Relationship between acute coronary syndrome and sudden changes in lipid profile. Chinese Journal of Cardiovascular Review, 2007, 6(5): 417-419.
Published
2023-03-02
Issue
Vol 11, No 4 (2022)
Section
Original Research Article

Copyright (c) 2023 Honglei Jiang

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