Impact of Rhabdomyosarcoma (RMS) Characteristics on Prognosis of Pediatric RMS: a SEER Database Large Population Study
Keywords:
Rhabdomyosarcoma, Prognosis, Subtype, Survival, Surgery, SEER
Abstract
To provide a better insight into the epidemiology, characteristics, therapeutics, and outcomes of pediatric RMS. Data of 1,623 pediatric RMS were acquired from the Surveillance, Epidemiology and End Results (SEER) database. Detailed information on demographics, primary site, size, subtype, stage, surgery, and survival had been recorded during 1975-2016. The most common subtype was embryonal RMS (64.9%) followed by alveolar RMS (29.9%). Additionally, the majority of RMS size was larger than 5 cm. Multivariable analysis exhibited that the age over 10, unfavorable primary site, distant metastasis was respectively correlated with the poor OS, whereas surgery could improve the outcomes of pediatric RMS. In conclusion, our large population-based analysis described that age, subtype, primary tumor sites, stage and surgery are all independent prognosis factors for RMS.References
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[2] Company, F., M. Pedram, and N. Rezaei, Clinical characteristics and the prognosis of childhood rhabdomyosarcoma in 60 patients treated at a single institute. Acta Med Iran, 2011. 49(4): p. 219-24.
[3] Kirsch, C.H., M. Goodman, and N. Esiashvili, Outcome of female pediatric patients diagnosed with genital tract rhabdomyosarcoma based on analysis of cases registered in SEER database between 1973 and 2006. Am J Clin Oncol, 2014. 37(1): p. 47-50.
[4] El-Kholy, E., et al., Added predictive value of 18F-FDG PET/CT for pediatric rhabdomyosarcoma. Nucl Med Commun, 2019.
[5] Ren, S., et al., Prognostic factors for postoperative survival among patients with rhabdomyosarcoma of the limbs. Cancer Manag Res, 2018. 10: p. 4181-4189.
Published
2022-03-29
Issue
Section
Original Research Article
Copyright (c) 2022 Lin Wan
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