A Retrospective Study on the Timing of Perioperative Antimicrobial Interventions in Class I Incisions

Abstract

 This retrospective case-control study was conducted to provide reference for the timing of antimicrobial drug use for clinical prevention. Cases of patients with type I incision surgery of 2019 at a 3A hospital were selected for statistical analysis, and 336 cases each with surgical duration ≥3h and equivalent surgical duration <3h of the same type were selected as the case and control groups, respectively. The focus was on the type of surgery, length of surgery, timing of medication, days of medication, and the occurrence or not of surgical site infection (SSI)in patients. There was a significant difference in the incidence of SSI between the case and control groups (18.15% Vs. 6.15%, P<0.001). The number of cases of intraoperative additional antimicrobial drugs for surgical duration ≥3h was 155 (57.83%), of which the number of cases with SSI was 40 and the number of cases with SSI without additional 113 was 21 (25.81% Vs. 18.58%, P=0.145). Additional intraoperative antimicrobial drugs for surgery ≥3 h were not effective in reducing the incidence of SSI, but significantly reduced the number of days patients were hospitalized. The occurrence of SSI is related to many factors and should not be overly dependent on the use of antimicrobial drugs.