Comparison of Dronedarone and Amiodarone in Maintaining Sinus Rhythm of Paroxysmal Atrial Fibrillation
Keywords:
Dronedarone, Amiodarone, Paroxysmal Atrial Fibrillation
Abstract
Objective: To compare the Dronedarone and the Amiodarone in maintaining the sinus rhythm of paroxysmal atrial fibrillation. Method 80 cases of paroxysmal atrial fibrillation patients were randomly divided into the dronedarone group and the amiodarone group. All patients were monitored for ambulatory electrocardiogram, liver and kidney function, thyroid function and other adverse reactions after 1 month and 3 months. Results: After 1 month, there was no statistical difference in arrhythmias recurrence, thyroid dysfunction, liver and kidney dysfunction, other adverse reactions(P>0.05). After 3 months, the amiodarone group was superior to the downturn in control arrhythmias recurrence, while the traders’ group were better than the amiodarone group in the thyroid dysfunction (P<0.05). Conclusion: Compared with amiodarone, the advantage of drawdown is that it has fewer side effects, especially thyroid dysfunction.References
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[7] Mujovic' N, Dobrev D, Marinkovic' M, et al. The role of amiodarone in contemporary management of complex cardiac arrhythmias[J]. Pharmacol Res,2020,151:104521.
[8] Bogazzi F，Bartalena L，Gasperi M，et al． The various effects of amiodarone on thyroid function［J］． Thyroid，2001，11 ( 5 ) : 511-519.
[9] Singh BN, Connolly SJ, Crijns HJ, et al. Dronedarone for maintenance of sinus rhythm in atrial fibrillation or flutter. N Engl J Med. 2007, 357:987-999.
[10] Connolly S J, Camm A J, Halperin J L, et al. Dronedarone in high-risk permanent atrial fibrillation[J]. N Eng L Med，2011，365（24）：2268-2276.
[2] Patel PD, Bhuriya R, Patel DD, et al. Dronedarone for atrialfibrillation: a new therapeutic agent[J]. Vasc Health RiskManag,2009,5:635 642.
[3] Sun W, Sarma JS. Electrophysiological effects of dronedarone, a noniodinate benzofuran derivative, in the rabbit heart: comparison with amiodarone. Circulation, 1999; 100: 2276-2281.
[4] Patel C, Yan GX, Kowey PR. Dronedarone[J]. Circulation, 2009, 120(7): 636 644.
[5] Heijman J, Heusch G, Dobrev D. Pleiotropic effects of antiarrhythmic agents: dronedarone in the treatment of atrial fibrillation[J]. Clin Med Insights Cardiol, 2013, 7: 127 140.
[6] Singh BN, Connolly SJ, Crijns HJ, et al. Dronedarone for maintenance of sinus rhythm in atrial fibrillation or flutter[J]. N Engl J Med, 2007, 357(10): 987 999.
[7] Mujovic' N, Dobrev D, Marinkovic' M, et al. The role of amiodarone in contemporary management of complex cardiac arrhythmias[J]. Pharmacol Res,2020,151:104521.
[8] Bogazzi F，Bartalena L，Gasperi M，et al． The various effects of amiodarone on thyroid function［J］． Thyroid，2001，11 ( 5 ) : 511-519.
[9] Singh BN, Connolly SJ, Crijns HJ, et al. Dronedarone for maintenance of sinus rhythm in atrial fibrillation or flutter. N Engl J Med. 2007, 357:987-999.
[10] Connolly S J, Camm A J, Halperin J L, et al. Dronedarone in high-risk permanent atrial fibrillation[J]. N Eng L Med，2011，365（24）：2268-2276.
Published
2021-12-27
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Section
Original Research Article
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