Research progress of insulin resistance in alcoholic liver disease
Keywords:
Alcoholic fatty liver, Insulin resistance, insulin signaling pathway
Abstract
Alcoholic liver disease (ALD) is a liver disease caused by long-term heavydrinking, but its pathogenesis is relatively complex, among which Insulin resistance(IR) is closely related to the formation of ALD. In this paper, the epidemiological status of ALD at home and abroad and the research progress of insulin resistance in alcoholic liver were
reviewed from the relationship between ALD and IR.
References
[1] Chen Xu, Wang Jianguo.Metabolism of ethanol in the body and its damage to the organism [J]. Science and Technology Information,2008(35):460
[2] Xie Y D, Zhao C Q, Wang J P,et al. Alcohol consumption analysis among patients with liver disease in China[J]. Chinese Medical Journal, 2019, 132 (4) : 420-430.Hepatology, 2010, 51 (1):227. (in Chinese with English abstract)
[3] Hailey J, Hailey J, McCullough J, et al. Alcoholic liver disease: A review [J]. Hepatology, 2010, 51(1):227.
[4] Dou Huixin, Zhang Dejun.Genomics and Applied Biology, 2016,35(07):1643-1647. (in Chinese with English abstract)
[5] Zhou FY, Yang YF, SHI Y. Research on insulin and insulin resistance signal transduction pathway in type 2 diabetes
mellitus [J]. Journal of Liaoning University of Traditional Chinese Medicine,2016,18(11):71-73.
[6] Pathogenesis-related pathogenesis-related liver disease by pathogenesis-related pathogenesis-related pathogenesis-related
liver disease by pathogenesis-related pathogenesis-related liver disease [J]. Classical concepts and recent advances[J]. Journal of Gastroenterology & Hepatology, 2011, 26(7):1089-1105.
[7] Longato Lisa, Ripp Kelsey, Setshedi Mashiko,et al. Insulin Resistance, Ceramide Accumulation,and Endoplasmic Reticulum Stress in Human Chronic Alcohol-Related Liver Disease[J]. Oxidative Medicine and Cellular Longevity, 2012:1-17.
[8] S M D L, Yeon J E, Tong M,et al. Insulin resistance in experimental alcohol-induced liver disease[J]. Journal of Gastroenterology and Hepatology, 2008, 23(8 Pt 2):e477-86.
[9] Perry R J, Samuel V T, Petersen K F,et al. The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes[J]. Nature, 2014, 510(7503):84-91.
[10] Acute ethanol exposure inhibits insulin signaling in the liver[J]. Hepatology, 2018, 44 (2) : 143-151. [10] Hansen J,
Hansen J, Hansen J, et al.2007, 46 (6).
[11] Liu W, Cao H, Ye C,Et al. Hepatic miR-378 targets p110α and controls glucose and lipid homeostasis by modulating
Hepatic insulinsignalling[J]. Nature Communications, 2014, 5:5684.
[12] Zheng Xiaoke, Wang Weiwei, Feng Shengjian.Journal of Clinical Medicine,2012,21(23):2763-2770. (in Chinese
with English abstract)
[13] bass.Inhibition of protein kinase B(PKB/Akt) activity in the pathogenesis of alcoholic fatty liver disease [C].Chinese Society of Toxicology, Hubei Association for Science and Technology.Proceedings of the 7th National Congress of Toxicology and the 8th Hubei Science and Technology Forum of Chinese Society of Toxicology.Chinese Society of Toxicology, Hubei Association for Science and Technology: Chinese Society of Toxicology,2015:390.
[14] Wang Y, Tong J, Zou D,et al. Elevated expression of forkhead box protein O1 (FoxO1) in alcohol-induced intestinal barrier dysfunction[J]. Acta Histochemica, 2013, 115(6):557-563.
[15] Bourogaa E, Riadh Nciri.... Antioxidant activity and hepatoprotective potential of Hammada scopariaagainst ethanol-induced liver injury in rats[J]. Journal of Physiology & Biochemistry, 2013, 69(2):227-237.
[16] Jinyao, Liu. Ethanol and Liver: Recent insights into the mechanisms of breeding of ethanol-induced fatty liver[J]. World Journal of Gastroenterology: English Journal, 2014(40):14672-14685.
[17] Hepatology, 2009, 50(3). (in Chinese with English abstract)
[18] Tan X, Sun X, Li Q,et al. Leptin Deficiency Contributes to the Pathogenesis of Alcoholic Fatty Liver Disease in Mice[J]. American Journal of Pathology, 2012, 181(4):1279-1286.
[19] Liu Jiangzheng.Study on the key role and mechanism of insulin signaling in alcoholic liver injury [D]. Fourth Military
Medical University,2015.
[20] Hoek J B, Rubin R, Thomas R, et al.A P. Ethanol-induced phospholipase C activation is inhibited by phorbol esters in isolated hepatocytes[J]. Biochemical Journal, 251(3):865-871.
[21] Carr R M, Giselle P, Xiaoyan Y, et al. Effect of Perilipin on the activity of Hepatic Steatosis.Glucose Intolerance and Ceramide Accumulation in Alcohol-Fed Mice[J]. Plos One, 2014, 9(5):e97118-.
[22] Parlesak A, Scha ¤fer C, Scha ¼ Tz T,et al. Increased intestinal permeability to macromolecules and endotoxemia
in patients with chronic alcohol abuse in Journal of Hepatology, 2000,32(5):742-747. (in Chinese with English abstract)
[J]. Hepatology, 2000,32(5):742-747.
[23] LI Jian, GUO Xiaolin.Intestinal fungal dysregulation and systemic immune response in patients with alcoholic hepatitis
[J].Journal of Clinical Hepatobiliary Diseases, 2019, 35(9).
[24] Kahlik K, Kahlik K, Kahlik K, et al. Fatty liver disease from alcohol-induced liver disorders: a meta-analysis [J] Gastroenterology, 2018, 24(36):15-29.
[2] Xie Y D, Zhao C Q, Wang J P,et al. Alcohol consumption analysis among patients with liver disease in China[J]. Chinese Medical Journal, 2019, 132 (4) : 420-430.Hepatology, 2010, 51 (1):227. (in Chinese with English abstract)
[3] Hailey J, Hailey J, McCullough J, et al. Alcoholic liver disease: A review [J]. Hepatology, 2010, 51(1):227.
[4] Dou Huixin, Zhang Dejun.Genomics and Applied Biology, 2016,35(07):1643-1647. (in Chinese with English abstract)
[5] Zhou FY, Yang YF, SHI Y. Research on insulin and insulin resistance signal transduction pathway in type 2 diabetes
mellitus [J]. Journal of Liaoning University of Traditional Chinese Medicine,2016,18(11):71-73.
[6] Pathogenesis-related pathogenesis-related liver disease by pathogenesis-related pathogenesis-related pathogenesis-related
liver disease by pathogenesis-related pathogenesis-related liver disease [J]. Classical concepts and recent advances[J]. Journal of Gastroenterology & Hepatology, 2011, 26(7):1089-1105.
[7] Longato Lisa, Ripp Kelsey, Setshedi Mashiko,et al. Insulin Resistance, Ceramide Accumulation,and Endoplasmic Reticulum Stress in Human Chronic Alcohol-Related Liver Disease[J]. Oxidative Medicine and Cellular Longevity, 2012:1-17.
[8] S M D L, Yeon J E, Tong M,et al. Insulin resistance in experimental alcohol-induced liver disease[J]. Journal of Gastroenterology and Hepatology, 2008, 23(8 Pt 2):e477-86.
[9] Perry R J, Samuel V T, Petersen K F,et al. The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes[J]. Nature, 2014, 510(7503):84-91.
[10] Acute ethanol exposure inhibits insulin signaling in the liver[J]. Hepatology, 2018, 44 (2) : 143-151. [10] Hansen J,
Hansen J, Hansen J, et al.2007, 46 (6).
[11] Liu W, Cao H, Ye C,Et al. Hepatic miR-378 targets p110α and controls glucose and lipid homeostasis by modulating
Hepatic insulinsignalling[J]. Nature Communications, 2014, 5:5684.
[12] Zheng Xiaoke, Wang Weiwei, Feng Shengjian.Journal of Clinical Medicine,2012,21(23):2763-2770. (in Chinese
with English abstract)
[13] bass.Inhibition of protein kinase B(PKB/Akt) activity in the pathogenesis of alcoholic fatty liver disease [C].Chinese Society of Toxicology, Hubei Association for Science and Technology.Proceedings of the 7th National Congress of Toxicology and the 8th Hubei Science and Technology Forum of Chinese Society of Toxicology.Chinese Society of Toxicology, Hubei Association for Science and Technology: Chinese Society of Toxicology,2015:390.
[14] Wang Y, Tong J, Zou D,et al. Elevated expression of forkhead box protein O1 (FoxO1) in alcohol-induced intestinal barrier dysfunction[J]. Acta Histochemica, 2013, 115(6):557-563.
[15] Bourogaa E, Riadh Nciri.... Antioxidant activity and hepatoprotective potential of Hammada scopariaagainst ethanol-induced liver injury in rats[J]. Journal of Physiology & Biochemistry, 2013, 69(2):227-237.
[16] Jinyao, Liu. Ethanol and Liver: Recent insights into the mechanisms of breeding of ethanol-induced fatty liver[J]. World Journal of Gastroenterology: English Journal, 2014(40):14672-14685.
[17] Hepatology, 2009, 50(3). (in Chinese with English abstract)
[18] Tan X, Sun X, Li Q,et al. Leptin Deficiency Contributes to the Pathogenesis of Alcoholic Fatty Liver Disease in Mice[J]. American Journal of Pathology, 2012, 181(4):1279-1286.
[19] Liu Jiangzheng.Study on the key role and mechanism of insulin signaling in alcoholic liver injury [D]. Fourth Military
Medical University,2015.
[20] Hoek J B, Rubin R, Thomas R, et al.A P. Ethanol-induced phospholipase C activation is inhibited by phorbol esters in isolated hepatocytes[J]. Biochemical Journal, 251(3):865-871.
[21] Carr R M, Giselle P, Xiaoyan Y, et al. Effect of Perilipin on the activity of Hepatic Steatosis.Glucose Intolerance and Ceramide Accumulation in Alcohol-Fed Mice[J]. Plos One, 2014, 9(5):e97118-.
[22] Parlesak A, Scha ¤fer C, Scha ¼ Tz T,et al. Increased intestinal permeability to macromolecules and endotoxemia
in patients with chronic alcohol abuse in Journal of Hepatology, 2000,32(5):742-747. (in Chinese with English abstract)
[J]. Hepatology, 2000,32(5):742-747.
[23] LI Jian, GUO Xiaolin.Intestinal fungal dysregulation and systemic immune response in patients with alcoholic hepatitis
[J].Journal of Clinical Hepatobiliary Diseases, 2019, 35(9).
[24] Kahlik K, Kahlik K, Kahlik K, et al. Fatty liver disease from alcohol-induced liver disorders: a meta-analysis [J] Gastroenterology, 2018, 24(36):15-29.
Published
2021-07-22
Issue
Section
Original Research Article
Copyright (c) 2021 Yan Zhang
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors submitting to USP journals agree to publish their manuscript under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0) where authors agree to allow third parties to share their work (copy, distribute, transmit) and to adapt it, under the condition that the authors are given credit, and that in the event of reuse or distribution, the terms of this license are made clear
Authors retain copyright of their work, with first publication rights (online and print) granted to Universe Scientific Publishing or the owner of the journal in question.
