Prion Interaction with Normal Protein in Topological Changing Secondary Structure to Aggregation

  • Yao Yao
DOI: https://doi.org/10.18686/aem.v9i2.167
Keywords: Prion, α-helix, β-sheet, Hydrogen Bond, Aggregation

Abstract

Prion is a protein smaller than virus and it infects host in the absence of nucleic acid. The secondary structure of protein folds incorrectly from α-helices to β-sheets through breaking and re-formation of hydrogen bond. Structural analogy of α-helix and DNA double helix and comparing differences between α-helix and β-sheet show prion's infectivity and propagation. Aggregates of dimers and polymers generate β-amyloid fibril in Alzheimer's disease.

References

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Published
2020-06-25
Issue
Vol 8 No 2 (2019)
Section
Original Research Article

Copyright (c) 2020 Yao Yao

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