Influence of Cinepazide Maleate on Vascular Endothelial Function of Patients with Acute Myocardial Infarction
Keywords:
Acute myocardial infarction, Vascular endothelial function, Cinepazide maleate
Abstract
Objective: To study influence of cinepazide maleate on vascular endothelial function of patients with acute myocardial infarction. Methods: 150 cases of patients with acute myocardial infarction were divided into the observation group and the control group, two groups were treated by conventional therapy about acute myocardial infarction, the observation group added 5%GS250 mL + cinepazide maleate 160 mg IV drip q.d, the control group added 5%GS250 mL IV drip q.d, the treatment course were 3 weeks, changes of vascular endothelial function and the blood serum no level before and after treatment were detected. Result: vascular endothelial function after treatment in observation group were obviously improved than that before treatment (p = 0.03) , blood serum no level was obviously increased (p ﹤ 0.05); about 3 weeks after treatment, vascular endothelial function in the observation group was obviously better than that of the control group (p = 0.04), the blood serum no level of the observation group was obviously higher than that of the control group (p ﹤ 0.05). Conclusion: Cinepazide maleate remarkably improves vascular endothelial function of patients with acute myocardial infarction.References
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2. Sun JA, Fu XH. Diagnosis and treatment of ST - segment elevation acute myocardial infarction. Clinical focus. 2004;19(3):131–134.
3. Zhang XX, Han PH. Pharmacological action and clinical application of cinepazide maleate. China pharmacy. 2007;18(26):2060–2062.
4. Geng HY, Wang SH. Practical therapeutics. Beijing : people's medical publishing house. 2006:1060–1061.
5. Yang L, Xia Y, Li XJ, et al. Evaluation of Doppler guide wire on adenosine preconditioning protection of coronary microcirculation function. Journal of clinical cardiology. 2004;20(6):357–359.
6, Zhou XQ, Chen S. Cinepazide maleate in treatment of unstable angina pectoris. The journal of practical medicine. 2009;25(2):272–273.
7. Zhao LJ. Cinepazide maleate injection on unstable angina pectoris analysis. Journal of jilin college of pharmacy. 2010;31(4):198–192.
8. Wang HP, Lu ZG. Effect observation of cinepazide maleate combined with xuesaitong injection on unstable angina pectoris. Guangdong medical journal. 2009;30(11):1735–1736.
9. Luo XH, Hu HH, Ma Y. Cinepazide maleate combined with irbesartan in treatment of 25 cases of senile hypertension complicated with coronary heart disease angina pectoris. Shaanxi Medical Journal. 2009;39(8):1045–1046.
10. Cheng J, Wang ZL, Zhao HC. Combination of sodium tanshinone IIA sulfonate and cinepazide maleate in treatment of angina pectoris. Shandong medical journal. 2011;51(17):71–72.
11. YU MS, Liang TS, et al. Clinical research of improvement of cinepazide maleate on vascular endothelial function in type 2 diabetic patients. Shandong pharmaceutical. 2009;49(24):79–80.
Published
2015-09-13
Issue
Section
Original Research Article
Copyright (c) 2015 Jiaming Niu, Zhaoling Ma
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