MicroRNAs and Lipid Metabolism

Jun Lu


Lipid metabolism is closely related to the occurrence and development of various diseases, and microRNAs, as important post-transcriptional regulatory factors, are involved in various biological processes of adipocyte differentiation and lipid metabolism to regulate lipid metabolism. In this paper, the effects of miRNAs on adipocyte differentiation, lipid synthesis, decomposition and transport reported in recent years are reviewed, with the hope of promoting the mechanism of microRNA in lipid metabolism disorders.


Lipid, Metabolism, MiRNAs

Full Text:



R.C. Lee, R.L. Feinbaum, V. Ambros, The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14, Cell, 75 (1993) 843-854.

Y. Zhang, X. Wu, C. Liang, P. Bao, X. Ding, M. Chu, C. Jia, X. Guo, P. Yan, MicroRNA-200a regulates adipocyte differentiation in the domestic yak Bos grunniens, Gene, 650 (2018) 41-48.

A. Acharya, D.C. Berry, H. Zhang, Y. Jiang, B.T. Jones, R.E. Hammer, J.M. Graff, J.T. Mendell, miR-26 suppresses adipocyte progenitor differentiation and fat production by targeting Fbxl19, Genes Dev, 33 (2019) 1367-1380.

J. Xu, microRNA-16-5p promotes 3T3-L1 adipocyte differentiation through regulating EPT1 Biochem Biophys Res Commun. 2019 Jul 5;514(4):1251-1256.

Y. Zhang, X. Wu, C. Liang, P. Bao, X. Ding, M. Chu, C. Jia, X. Guo, P. Yan, MicroRNA-200a regulates adipocyte differentiation in the domestic yak Bos grunniens, Gene, 650 (2018) 41-48.

M. Alves-Bezerra, D.E. Cohen, Triglyceride Metabolism in the Liver, Compr Physiol, 8 (2017) 1-8.

W.C. Tsai, S.D. HsuMicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis, J Clin Invest, 122 (2012) 2884-2897.

C. Chai, M. Rivkin, L. Berkovits, A Metabolic Circuit Involving Free Fatty Acids, microRNA 122, and Triglyceride Synthesis in Liver and Muscle Tissues, Gastroenterology, 153 (2017) 1404-1415.

F. Kostopoulou, K.N. Malizos, I. Papathanasiou, A. Tsezou, MicroRNA-33a regulates cholesterol synthesis and cholesterol efflux-related genes in osteoarthritic chondrocytes, Arthritis Res Ther, 17 (2015) 42.

C.M. Paton, J.M. Ntambi, Biochemical and physiological function of stearoyl-CoA desaturase, Am J Physiol Endocrinol Metab, 297 (2009) E28-37.

X. Cheng, Q.Y. Xi, S. Wei, D. Wu, R.S. Ye, T. Chen, Q.E. Qi, Q.Y. Jiang, S.B. Wang, L.N. Wang, X.T. Zhu, Y.L. Zhang, Critical role of miR-125b in lipogenesis by targeting stearoyl-CoA desaturase-1 (SCD-1), J Anim Sci, 94 (2016) 65-76.

H. Bhatia, G. Verma, M. Datta, miR-107 orchestrates ER stress induction and lipid accumulation by post-transcriptional regulation of fatty acid synthase in hepatocytes, Biochim Biophys Acta, 1839 (2014) 334-343.

L. Fan, R. Lai, N. Ma, Y. Dong miR-552-3p modulates transcriptional activities of FXR and LXR to ameliorate hepatic glycolipid metabolism disorder, J Hepatol, 74 (2021) 8-19.

D. Zhong, MicroRNA-1 and microRNA-206 suppress LXRα-induced lipogenesis in hepatocytes Cell Signal. 2013 Jun; 25(6): 1429-37

R. Zechner, R. Zimmermann, T.O. Eichmann, S.D. Kohlwein, G. Haemmerle, A. Lass, F. Madeo, FAT SIGNALS--lipases and lipolysis in lipid metabolism and signaling, Cell Metab, 15 (2012) 279-291.

E. Tvrzicka, Fatty acids as biocompounds: their role in human metabolism, health and disease--a review. Part 1: classification, dietary sources and biological functions Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2011 Jun;155(2):117-30.

T.Q. de Aguiar Vallim, E.J. Tarling, P.A. Edwards, Pleiotropic roles of bile acids in metabolism, Cell Metab, 17 (2013) 657-669.

T. Zhang, A negative feedback loop between microRNA-378 and Nrf1 promotes the development of hepatosteatosis in mice treated with a high fat diet Metabolism. 2018 Aug; 85:183-191.

A.N. Mattis, A screen in mice uncovers repression of lipoprotein lipase by microRNA-29a as a mechanism for lipid distribution away from the liver Hepatology. 2015 Jan;61(1):141-52, 2015.

Y. Yang, Q. Pan, B. Sun, R. Yang, X. Fang, X. Liu, X. Yu, Z. Zhao, miR-29b Targets LPL and TDG Genes and Regulates Apoptosis and Triglyceride Production in MECs, DNA Cell Biol, 35 (2016) 758-765.

D. Gatfield, G. Le Martelot, C.E. Vejnar, D. Gerlach, O. Schaad, F. Fleury-Olela, A.L. Ruskeepaa, M. Oresic, C.C. Esau, E.M. Zdobnov, U. Schibler, Integration of microRNA miR-122 in hepatic circadian gene expression, Genes Dev, 23 (2009) 1313-1326.

Q. Zhang, X.F. Ma, M.Z. Dong, J. Tan, J. Zhang, L.K. Zhuang, S.S. Liu, Y.N. Xin, MiR-30b-5p regulates the lipid metabolism by targeting PPARGC1A in Huh-7 cell line, Lipids Health Dis, 19 (2020) 76.

A. Sirwi, M.M. Hussain, Lipid transfer proteins in the assembly of apoB-containing lipoproteins, J Lipid Res, 59 (2018) 1094-1102.

J.Z.F.R. JaziI, miR-130b is a potent stimulator of hepatic very-low-density lipoprotein assembly and secretion via marked induction of microsomal triglyceride transfer protein Am J Physiol Endocrinol Metab. 2020 Feb 1;318(2):E262-E275., 2020.

Z. Ma, H. Li, H. Zheng, K. Jiang, L. Jia, F. Yan, Y. Tian, X. Kang, Y. Wang, X. Liu, MicroRNA-101-2-5p targets the ApoB gene in the liver of chicken (Gallus Gallus), Genome, 60 (2017) 673-678.

L.Zhou, M.M. Hussain, Human MicroRNA-548p Decreases Hepatic Apolipoprotein B Secretion and Lipid Synthesis, Arterioscler Thromb Vasc Biol, 37 (2017) 786-793.

J. Soh, J. Iqbal, J. Queiroz, C. Fernandez-Hernando, M.M. Hussain, MicroRNA-30c reduces hyperlipidemia and atherosclerosis in mice by decreasing lipid synthesis and lipoprotein secretion, Nat Med, 19 (2013) 892-900.

K.C. Vickers, K.J. Moore, Small RNA overcomes the challenges of therapeutic targeting of microsomal triglyceride transfer protein, Circ Res, 113 (2013) 1189-1191.

J. Soh, M.M. Hussain, Supplementary site interactions are critical for the regulation of microsomal triglyceride transfer protein by microRNA-30c, Nutr Metab (Lond), 10 (2013) 56.

J. Kim, MiR-106b impairs cholesterol efflux and increases Aβ levels by repressing ABCA1 expression Exp Neurol. 2012 Jun; 235 (2):476-83.

Z. Wang, MiR‑30e and miR‑92a are related to atherosclerosis by targeting ABCA1 Mol Med Rep. 2019 Apr; 19 (4):3298-3304.

DOI: http://dx.doi.org/10.18686/aem.v10i3.203


  • There are currently no refbacks.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.