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Prion Interaction with Normal Protein in Topological Changing Secondary Structure to Aggregation

Yao Yao

Abstract


Prion is a protein smaller than virus and it infects host in the absence of nucleic acid. The secondary structure of protein folds incorrectly from α-helices to β-sheets through breaking and re-formation of hydrogen bond. Structural analogy of α-helix and DNA double helix and comparing differences between α-helix and β-sheet show prion's infectivity and propagation. Aggregates of dimers and polymers generate β-amyloid fibril in Alzheimer's disease.


Keywords


Prion; α-helix; β-sheet; Hydrogen Bond; Aggregation

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References


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DOI: http://dx.doi.org/10.18686/aem.v9i2.167

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