Page Header

Research Progress on the Relevance between Intestinal Flora and Colorectal Cancer

Yang Hui, Junming Hou, Yong Jia, Ming Dong, Feixue Feng, Jing Jiang, Dezhen Yang

Abstract


Cancer is a common chronic disease all over the world, which will cause serious health burden. At present, the debate about the role of intestinal flora in the prevention and control of cancer has always existed. Therefore, researchers should pay close attention to the impact of intestinal flora on several cancers (such as colon cancer, liver cancer and breast cancer). In addition, it is reported that intestinal flora may also affect the efficacy of cancer chemotherapy and immunotherapy. This paper introduces some energy research results to help clear the relationship between intestinal flora and cancer, even cancer micro environment. It can help clarify the mist of cancer and gut microbiota, let those little creatures to serve the progress of improving mankind living condition and of health and medicine.


Keywords


Intestinal Flora; Colorectal Cancer; Anti-cancer; Mechanism of Cancer Micro Environment; Review

Full Text:

PDF

References


Ahmedin J, Freddie B, Melissa MC, et al. Global cancer statistics. CA: A Cancer Journal for Clinicians 1900; 61(2): 69-90. doi: 10.3322/caac.20107.

Lozupone CA, Stombaugh JI, Gordon JI, et al. Diversity, stability and resilience of the human gut microbiota. Nature 2012; 489(7415): 220-30. doi: 10.1038/nature11550.

Zhan H. The relationship between intestinal flora and colorectal cancer (in Chinese). Chinese Cancer Clinic 2015; 42(13): 675-679.

Ulger TN, Yagci A, Gulluoglu BM, et al. A possible role of bacteroides fragilis enterotoxin in the aetiology of colorectal cancer. Clinical Microbiology and Infection 2006; 12(8): 782-786. doi: 10.1111/j.1469-0691.2006.01494.x.

Pauline DS, Fergus S, Yvonne C, et al. Culture-independent analysis of the gut microbiota in colorectal cancer and polyposis. Environmental Microbiology 2008; 10(3): 789-798. doi: 10.1111/j.1462-2920.2007.01503.x.

Sobhani I, Tap J, Roudot TF, et al. Microbial dysbiosis in colorectal cancer (CRC) patients. PloS one 2011; 6(1): e16393. doi: 10.1371/journal.pone.0016393.

Wang T, Cai G, Qiu Y, et al. Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers. Isme Journal 2012; 6(2): 320-329. doi: 10.1038/ismej.2011.109.

Wu N, Yang X, Zhang R, et al. Dysbiosis signature of fecal microbiota in colorectal cancer patients. Microbial Ecology 2013; 66(2): 462-470. doi: 10.1007/s00248-013-0245-9.

Takeda K, Suzuki T, Shimada SI, et al. Interleukin-12 is involved in the enhancement of human natural killer cell activity by lactobacillus casei shirota. Clinical and Experimental Immunology 2006; 146(1): 109-115. doi: 10.1111/j.1365-2249.2006.03165.x.

Frick JS, Autenrieth IB. The gut microflora and its variety of roles in health and disease. Current Topics in Microbiology & Immunology 2013; 358: 273-289. doi: 10.1007/82_2012_217.

Liu M, Zhang J, Chen S, et al. Effect of TLRs on lipoteichoic acid of bifidobacterium inducing colon cancer cells apoptosis. Chinese Journal of Microecology 2008; 20(2): 116-119. doi: 10.3969/j.issn.1005-376X.2008.02.007.

Abdulamir AS, Hafidh RR, Bakar FA. Molecular detection, quan- tification, and isolation of streptococcus gallolyticus bacteria colonizing colorectal tumors: Inflammation-driven potential of carcino-genesis via IL-1, COX-2, and IL-8. Mol Cancer 2010; 9: 249.

Marchesi JR. Human distal gut microbiome. Environmental Microbiology 2011; 13(12): 3088-3102. doi: 10.1111/j.1462-2920.2011.02574.x.

Chen W, Liu F, Ling Z, et al. Human intestinal lumen and mucosa-associated microbiota in patients with colorectal cancer. PloS one 2012; 7(6): e39743. doi: 10.1371/journal.pone.0039743.

Wang W, Chen L, Zhou R, et al. Increased proportions of bifidobacterium and the lactobacillus group and loss of butyrate-producing bacteria in inflammatory bowel disease. Journal of Clinical Microbiology 2013; 52(2): 398-406. doi: 10.1128/JCM.01500-13.

Ivanov K, Kolev N, Tonev A, et al. Comparative analysis of prognostic significance of molecular markers of apoptosis with clinical stage and tumor differentiation in patients with colorectal cancer: a single institute experience. Hepato Gastroenterology 2009; 56(89): 94-98. doi: 10.1016/S0168-583X(98)00259-6.

Wu S, Rhee KJ, Zhang M, et al. Bacteroides fragilis toxin stimulates intestinal epithelial cell shedding and γ-secretase-dependent E-cadherin cleavage. Journal of Cell Science 2007; 120(Pt 11): 1944-1952. doi: 10.1242/jcs.03455.

Remacle AG, Shiryaev SA, Strongin AY. Distinct interactions with cellular e-cadherin of the two virulent metalloproteinases encoded by a bacteroides fragilis pathogenicity island.PloS one 2014; 9(11): e113896.

Tao J, Li S, Gan R, et al. Targeting gut microbiota with dietary components on cancer: Effects and potential mechanisms of action. Critical Reviews in Food Science & Nutrition 2020; 60: 1025-1037. doi: 10.1080/10408398.2018.1555789.




DOI: http://dx.doi.org/10.18686/aem.v9i2.165

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.