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An Experimental Study on the Establishment of Pulmonary Hypertension Model in Rats induced by Monocrotaline

Zhongshuang Zhang, Xiaoyong Song, Zhengyong Zhao, Jiazheng Xu, Shu Luo, Jiawang Ma, Ruiyang Zhao, Jiahao Fu, Xudong Wang, Wenxin Zhu, Yaohui Hu, Chunyuan Xue, Yongxiang Liu, Jinniu Guo, Ruihong Lu, Youzhi Wu, Wenxing Gao, Bowen Wu, Wenwei Li, Guohong Gong, Runze Shi, Guangsen Lu

Abstract


Pulmonary hypertension is called PH for short. It is caused by the pulmonary artery vascular disease leading to pulmonary vascular resistance, and the increase right lung compartment load, which resulting in weakening or even collapse of the right ventricular function. The establishment of rat PH model under the action of monocrotaline is a repeatable, simple and accessible operation technique, which has been widely used in the treatment of pulmonary hypertension. This paper discusses the principle and properties of the PH model on rats under the monocrotaline action.

Keywords


onocrotaline; Induction; Pulmonary Hypertension; Model Constructio

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Citations


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DOI: http://dx.doi.org/10.18686/aem.v9i1.161

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