An Experimental Study on the Establishment of Pulmonary Hypertension Model in Rats induced by Monocrotaline
Keywords:
Monocrotaline, Induction, Pulmonary Hypertension, Model Construction
Abstract
Pulmonary hypertension is called PH for short. It is caused by the pulmonary artery vascular disease leading to pulmonary vascular resistance, and the increase right lung compartment load, which resulting in weakening or even collapse of the right ventricular function. The establishment of rat PH model under the action of monocrotaline is a repeatable, simple and accessible operation technique, which has been widely used in the treatment of pulmonary hypertension. This paper discusses the principle and properties of the PH model on rats under the monocrotaline action.References
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[2] Li B, He W. Theoretical research and preparation characteristics of animal model of pulmonary hypertension (in Chinese). Chinese Journal of Tissue Engineering Research 2010; 14(11): 2039-2042.
[3] Wang J, Yang D, Li Z, et al. Establishment of rat model of pulmonary hypertension induced by lilium (in Chinese). Chinese Journal of Tissue Engineering Research 2011; 15(28): 5237-5240.
[4] Yang L, Chen D, Zhou D. Establishment of pulmonary arterial hypertension model in rats induced by different doses of choline (in Chinese). Chinese Journal of Clinical Pharmacy 2008; 27(1): 36-39.
[5] Dong L, Chen P, Cheng J. Experimental study on pulmonary arterial hypertension induced by different doses of choline in rats (in Chinese). Chinese Journal of Integrative Medicine on Cardio Cerebrovascular Disease 2015; 13(10): 1172-1175.
[6] Zhu J, Chen H, Zhao X, et al. Effect of monophosphate induced pulmonary hypertension on the expression of hippo signaling pathway in rats (in Chinese). Chinese Journal of Pathophysiology; 35(7): 1333-1338.
Published
2020-03-18
Issue
Section
Original Research Article
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