Page Header

An Experimental Study on the Establishment of Pulmonary Hypertension Model in Rats induced by Monocrotaline

Zhongshuang Zhang, Xiaoyong Song, Zhengyong Zhao, Jiazheng Xu, Shu Luo, Jiawang Ma, Ruiyang Zhao, Jiahao Fu, Xudong Wang, Wenxin Zhu, Yaohui Hu, Chunyuan Xue, Yongxiang Liu, Jinniu Guo, Ruihong Lu, Youzhi Wu, Wenxing Gao, Bowen Wu, Wenwei Li, Guohong Gong, Runze Shi, Guangsen Lu


Pulmonary hypertension is called PH for short. It is caused by the pulmonary artery vascular disease leading to pulmonary vascular resistance, and the increase right lung compartment load, which resulting in weakening or even collapse of the right ventricular function. The establishment of rat PH model under the action of monocrotaline is a repeatable, simple and accessible operation technique, which has been widely used in the treatment of pulmonary hypertension. This paper discusses the principle and properties of the PH model on rats under the monocrotaline action.


onocrotaline; Induction; Pulmonary Hypertension; Model Constructio

Full Text:



Qiu S, Huang S. Study on the mechanism of wild lilium induced pulmonary hypertension in animal model (in Chinese). China Medical Innovation 2016; 13(17): 142-145.

Li B, He W. Theoretical research and preparation characteristics of animal model of pulmonary hypertension (in Chinese). Chinese Journal of Tissue Engineering Research 2010; 14(11): 2039-2042.

Wang J, Yang D, Li Z, et al. Establishment of rat model of pulmonary hypertension induced by lilium (in Chinese). Chinese Journal of Tissue Engineering Research 2011; 15(28): 5237-5240.

Yang L, Chen D, Zhou D. Establishment of pulmonary arterial hypertension model in rats induced by different doses of choline (in Chinese). Chinese Journal of Clinical Pharmacy 2008; 27(1): 36-39.

Dong L, Chen P, Cheng J. Experimental study on pulmonary arterial hypertension induced by different doses of choline in rats (in Chinese). Chinese Journal of Integrative Medicine on Cardio Cerebrovascular Disease 2015; 13(10): 1172-1175.

Zhu J, Chen H, Zhao X, et al. Effect of monophosphate induced pulmonary hypertension on the expression of hippo signaling pathway in rats (in Chinese). Chinese Journal of Pathophysiology; 35(7): 1333-1338.



  • There are currently no refbacks.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.