Research Progress of CD73 in Cancer

Shuang Guo, Hongli Liu


CD73 (NT5E, extracellular 5' nucleotidase) is a multifunctional glycoprotein encoded by the NT5E gene with a relative molecular weight of 70 kD that can be anchored to the outer surface of cell membranes by glycosyl phosphatidylinositol (GPI).CD73 expression levels are aberrant in breast, colorectal, head and neck squamous cell carcinomas, gastric and hepatocellular carcinomas. However, the possible role and mechanism of CD73 in gastric carcinogenesis and development has not been clarified. In this paper, we will review the multiple roles of CD73 in tumour development, including the clinical significance of CD73, the promotion of tumour growth, metastasis and angiogenesis by CD73, the suppression of immune response by CD73, the regulatory mechanisms of CD73 expression, and the current status of CD73 anti-tumour therapy, with a view to providing a reference for subsequent studies.


CD73; Cancer; Antitumor Therapy; Regulatory Mechanism

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