Analysis of HER2 Gene Amplification and Certain Prognostic Factors in Breast Cancer

  • Xulong Zhu Shaanxi Provincial People’s Hospital & Xi’an Jiaotong University
  • Binliang Huo Shaanxi Provincial People’s Hospital
  • Jianhui Li Shaanxi Provincial People’s Hospital
  • Shuhan Wu Shaanxi Provincial People’s Hospital
  • Yangmeng Feng Shaanxi Provincial People’s Hospital
DOI: https://doi.org/10.18686/aem.v11i3.298
Keywords: Breast Cancer, HER2, Gene Amplification, Prognostic Factors

Abstract

Objective: The HER2 gene amplification and certain prognostic factors in breast cancer were analyzed. Method: The gene amplification and protein expression of human epidermal growth factor receptor in 100 breast cancer tissues detected by FISH and IHC detection method in the hospital from January 2020 to December 2021 were analyzed. To analyze some breast cancer prognostic factors. Result: 0 is 8 cases of HER-2 protein breast cancer, (1+) is 11 cases, (2+) is 49 cases, (3+) is 32 cases. The HER2 gene was amplified in 49 cases, of which 23 cases showed red signals in clusters, and 26 cases showed red signals in dots. 51 cases of HER-2 gene were not amplified. There are differences in the detection results of FISH and IHC detection methods (P＞0.05). ER, PR and polysomy of chromosome 17 are prognostic factors associated with HER2 gene amplification in certain breast cancers. (P＜0.05) Conclusion: To analyze the HER2 gene amplification in breast cancer and targeted select FISH and IHC detection methods can improve the therapeutic effect and prognostic factor, which deserves clinical attention.

References

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Published
2022-11-07
Issue
Vol 11 No 3 (2022)
Section
Original Research Article

Copyright (c) 2022 Xulong Zhu, Binliang Huo, Jianhui Li, Shuhan Wu, Yangmeng Feng

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