Regulating Intestinal Microbes to Decrease the Incidence of Heart Disease

  • Xingmei  Jin Northeastern University
DOI: https://doi.org/10.18686/aem.v11i3.284
Keywords: Intestinal Microbes, Heart Disease, Ways to Reduce TMAO

Abstract

This paper studies the correlation between intestinal microbes and heart disease. In the paper, the process of human body producing Trimethylamine-N-oxide (TMAO) under the role of intestinal microbes has been analyzed, and the ways to reduce the level of TMAO which can increase the incidence of heart disease has been designed. The expected result is that the level of TMAO in plasma is successfully reduced by regulating intestinal microbes. This paper can provide useful information for further studies in self-healing therapy by regulating intestinal microbes.

References

[1] Neish AS, “Microbes in Gastrointestinal Health and Disease.” Gastroenterology, 136.1 (2009): 65-80.

[2] Tang WH, Wilson, and Stanley, L. Hazen., “The Contributory Role of Gut Microbiota in Cardiovascular Disease.” The Journal of Clinical Investigation124.10 (2014): 4204–4211.

[3] Tang, W.H., Wilson, Wang, Z.N., Bruce, S., Levison, R. A., Koeth, Earl B. Britt, Fu, X.M., Wu, Y.P., and Stanley L. Hazen. “Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk.” The New England Journal of Medicine 368.17 (2013): 1575-584.

[4] Wang, T., Shrestha, Borowski, Wu, Troughton, Klein, and Hazen. “Intestinal Microbiota-Dependent Phosphatidylcholine Metabolites, Diastolic Dysfunction, and Adverse Clinical Outcomes in Chronic Systolic Heart Failure.” Journal of Cardiac Failure 21.2 (2015): 91-96.

[5] Trøseid, Ueland, Hov, Svardal, Gregersen, Dahl, Aakhus, Gude, Bjørndal, Halvorsen, Karlsen, Aukrust, Gullestad, Berge, and Yndestad. “Microbiota‐dependent Metabolite Trimethylamine‐N‐oxide Is Associated with Disease Severity and Survival of Patients with Chronic Heart Failure.” Journal of Internal Medicine 277.6 (2015): 717-26.

[6] Wang, Z.N., Elizabeth Klipfell, Brian J. Bennett, Robert Koeth, Bruce S. Levison, Brandon Dugar, Ariel E. Feldstein, Earl B. Britt, Fu, X.M., Chung, Y.M., Wu, Y.P., Phil Schauer, Jonathan D. Smith, Hooman Allayee, W. H. Wilson Tang, Joseph A. Didonato, Aldons J. Lusis, and Stanley L. Hazen. “Gut Flora Metabolism of Phosphatidylcholine Promotes Cardiovascular Disease.” Nature 472.7341 (2011): 57-63.
Published
2022-11-04
Issue
Vol 11 No 3 (2022)
Section
Original Research Article

Copyright (c) 2022 Xingmei  Jin

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Authors submitting to USP journals agree to publish their manuscript under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0) where authors agree to allow third parties to share their work (copy, distribute, transmit) and to adapt it, under the condition that the authors are given credit, and that in the event of reuse or distribution, the terms of this license are made clear

Authors retain copyright of their work, with first publication rights (online and print) granted to Universe Scientific Publishing or the owner of the journal in question.