Observation on Clinical Efficacy and Safety of Amiodarone in the Treatment of Malignant Arrhythmia after Acute Myocardial Infarction (AMI)

Abstract

To investigate the clinical efficacy and safety of ethylamine iodine in the treatment of malignant arrhythmia after acute myocardial infarction. Method: 35 patients with malignant arrhythmia after acute myocardial infarction were enrolled in our hospital from May 2013 to August 2014. The patients were treated with ethidium iodide load of 75-150 mg/times. The patients were treated with intravenous infusion of 0.5-1.0 mg/min micro pump at 15-20 min. The clinical curative effect and the heart rate were analyzed at 15 min, 1, 2 and 24 h after treatment respectively, mean arterial pressure changes and adverse reactions and so on. Results: The total effective rate was 91.43% in the clinical treatment. The heart rate, mean arterial pressure and the difference before treatment were significant (P <0.05) at 15 min, 1, 2, and 24 h after treatment and the drug dose was adjusted in 3 patients after bradycardia after return to the normal range. Conclusion: Ethylamine iodine can be used in the clinical treatment of acute myocardial infarction and malignant arrhythmia. It can achieve significant clinical curative effect, high safety and mild adverse reaction. It is worthy to be popularized and applied.