Study on the Risk of Metabolic Syndrome Based on UA/Cr Analysis

  • Huimin Zhang
Keywords: Ratio of Serum Uric Acid/Creatinine, Metabolic Syndrome, Middle Aged and Old People

Abstract

To explore the epidemiological trend of the relationship between serum uric acid/creatinine ratio(UA/Cr) and metabolic syndrome (MS) in middle-aged and old people in Wuhan, Hubei Province. The study used the method of cluster sampling, In 2016, 6570 residents over 45 years old in Wuhan City, Hubei Province were investigated with standardized questionnaire, physical examination and biochemical examination. MS is defined according to the standard of the International Diabetes Union. According to the quartile grouping of UA/Cr, the regression analysis of risk metabolism indexes between UA / Cr and MS was carried out. Analyze the correlation between UA / Cr and MS to determine whether UA / Cr can be an independent risk factor of MS.6414 subjects were included in this study including 3313 MS patients (52.7%). Blood CR level is 77(70~87) mmol/L,Blood UA level is 314(267~372) mmol/L,UA/Cr level is 4.01(3.46~4.65). The study population was divided into four groups according to the UA / Cr quartile.Group 1 UA/Cr <1.0, Group 2 1.0≤UA/Cr<1.5,Group 3 1.5≤UA/Cr<2.0,Group 4 UA/Cr≥2.0. From the first group to the fourth group, with the increase of UA / Cr level, the body mass index (BMI), waist circumference, blood pressure, triacylglycerol, low-density lipoprotein cholesterol, total cholesterol, C-reactive protein and insulin resistance increased gradually (P < 0.01). The prevalence of MS and its components also increased significantly (P < 0.01).Conclusion:There was an independent positive correlation between UA / Cr and MS in the middle-aged and old people in the community, UA / Cr can be used as early biomarker of MS. It provides a new scientific basis for the early detection of MS, the intervention of high-risk population and the reversal of cardiovascular disease.

References

[1] Weerasekera DS, Peiris H. The significance of serum uric acid, creatinine and urinary microprotein levels in predicting pre-eclampsia. Journal of Obstetrics & Gynaecology 2003;23(1):17-19. doi: 10.1080/0144361021000043155.
[2] Krajcoviechova A, Cifkova R, Wohlfahrt P, et al. 2B.07: Diastolic blood pressure modifies the association of uric acid with albumin/creatinine ratio in pre-metabolic syndrome. Journal of Hypertension 2015;33 Suppl 1 - ESH 2015 Abstract Book(5):e23-e24. doi: 10.1097/01.hjh.0000467412.94407.39.
[3] Krajcoviechova A, Tremblay J, Wohlfahrt P, et al. The Impact of Blood Pressure and Visceral Adiposity on the Association of Serum Uric Acid With Albuminuria in Adults Without Full Metabolic Syndrome. American Journal of Hypertension 2016:hpw098. doi: 10.1093/ajh/hpw098.
[4] Leoncini G, Ratto E, Viazzi F, et al. Metabolic syndrome is associated with early signs of organ damage in nondiabetic, hypertensive patients. Journal of Internal Medicine 2005;257(5):454-460. doi: 10.1111/j.1365-2796.2005.01468.x.
[5] Bhole V, Choi JWJ , Kim S W, et al. Serum Uric Acid Levels and the Risk of Type 2 Diabetes: A Prospective Study. The American Journal of Medicine 2010;123(10):0-961. doi: 10.1016/j.amjmed.2010.03.027.
[6] Lin C, Yu H, Lin F, et al. Effect of serum uric acid level on blood pressure response to antihypertensive drug in male hypertensives. Heart 2011;97(Suppl 3):A196-A197. doi: 10.1136/heartjnl-2011-300867.572.
[7] Al-Daghri NM, Al-Attas OS , Wani K, et al. Serum Uric Acid to Creatinine Ratio and Risk of Metabolic Syndrome in Saudi Type 2 Diabetic Patients. Scientific Reports 2017;7(1):12104. doi: 10.1038/s41598-017-12085-0.
[8] Liu P J, Ma F, Lou H P, et al. Relationship between serum uric acid levels and metabolic syndrome in Chinese postmenopausal women. Climacteric 2014;17(2):148-154. doi: 10.3109/13697137.2013.818969.
[9] Kawamoto R, Tomita H, Oka Y, et al. Relationship between Serum Uric Acid Concentration, Metabolic Syndrome and Carotid Atherosclerosis. Internal Medicine 2006;45(9):605-614. doi: 10.2169/internalmedicine.45.1661.
Published
2019-12-05
Section
Original Research Article